DegronMD

Uniprot ID: Q03164

Source protein: Histone-lysine N-methyltransferase 2A

Source gene: KMT2A

Class: DEG_SCF_FBW7_1

Location: 769:775

E3 ligase: FBXW7

DEGRON score: 0.9858

ASA_SCORE: 89.0429

COIL: 0.9593

CONS_SCORE: 0.3813

DSS_SCORE: 0.4748

HELIX: 0.0211

FCONS_SCORE: 0.9442

RIG_SCORE: 0.5761

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S775F	TCGA-4B-A93V	LUAD	TCGA	PLTPPSS	DEG_SCF_FBW7_1	0.7982
p.S775F	DO218926	LUAD	ICGC	PLTPPSS	DEG_SCF_FBW7_1	0.7982
p.S763T	DO233796	GACA	ICGC	PLTPPSS	DEG_SCF_FBW7_1	0.1667
p.S763G	SIDM00217	Colorectal Carcinoma	GDSC	PLTPPSS	DEG_SCF_FBW7_1	0.1667
p.S763G	ACH-000999	Colon/Colorectal Cancer	CCLE	PLTPPSS	DEG_SCF_FBW7_1	0.1667
p.S763G	SNU-1040	large_intestine	COSMIC	PLTPPSS	DEG_SCF_FBW7_1	0.1667
p.E766Q	SIDM01498	Acute Myeloid Leukemia	GDSC	PLTPPSS	DEG_SCF_FBW7_1	0.25
p.E766Q	ACH-000487	Leukemia	CCLE	PLTPPSS	DEG_SCF_FBW7_1	0.25
p.S764R	SIDM01588	Endometrial Carcinoma	GDSC	PLTPPSS	DEG_SCF_FBW7_1	0.1944
p.S764R	ACH-000993	Endometrial/Uterine Cancer	CCLE	PLTPPSS	DEG_SCF_FBW7_1	0.1944
p.S759N	ACH-000554	Breast Cancer	CCLE	PLTPPSS	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q03164	Histone-lysine N-methyltransferase 2A	DEG_SCF_FBW7_1	769:775	PLTPPSS	FBXW7	0.9858	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons