DegronMD

Uniprot ID: Q03164

Source protein: Histone-lysine N-methyltransferase 2A

Source gene: KMT2A

Class: DEG_SPOP_SBC_1

Location: 2810:2814

E3 ligase: SPOP

DEGRON score: 0.9894

ASA_SCORE: 91.58

COIL: 0.9108

CONS_SCORE: 0.3517

DSS_SCORE: 0.5603

HELIX: 0.0404

FCONS_SCORE: 0.8943

RIG_SCORE: 0.6393

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R2811C	TCGA-44-A4SS	LUAD	TCGA	VHTST	DEG_SPOP_SBC_1	0.8301
p.S2816N	TCGA-AX-A1CE	UCEC	TCGA	VHTST	DEG_SPOP_SBC_1	0.2778
p.R2812I	TCGA-AX-A2HC	UCEC	TCGA	VHTST	DEG_SPOP_SBC_1	0.8102
p.R2811H	TCGA-AX-A2HD	UCEC	TCGA	VHTST	DEG_SPOP_SBC_1	0.8244
p.P2818L	TCGA-BR-8590	STAD	TCGA	VHTST	DEG_SPOP_SBC_1	0.3333
p.T2815K	TCGA-CZ-4865	KIRC	TCGA	VHTST	DEG_SPOP_SBC_1	0.3056
p.S2819C	TCGA-IG-A3Y9	ESCA	TCGA	VHTST	DEG_SPOP_SBC_1	0.1944
p.D2802N	DO447	BLCA	ICGC	VHTST	DEG_SPOP_SBC_1	0.1111
p.D2801N	DO695	BLCA	ICGC	VHTST	DEG_SPOP_SBC_1	0.0833
p.C2803F	DO229019	LICA	ICGC	VHTST	DEG_SPOP_SBC_1	0.1389
p.D2801G	DO229054	LICA	ICGC	VHTST	DEG_SPOP_SBC_1	0.0833
p.D2802Y	DO219189	LUSC	ICGC	VHTST	DEG_SPOP_SBC_1	0.1111
p.P2808H	DO37406	SKCM	ICGC	VHTST	DEG_SPOP_SBC_1	0.2778
p.R2809I	DO41572	UCEC	ICGC	VHTST	DEG_SPOP_SBC_1	0.3056
p.S2819P	SIDM01767	Squamous Cell Lung Carcinoma	GDSC	VHTST	DEG_SPOP_SBC_1	0.1944
p.S2819P	ACH-000553	Lung Cancer	CCLE	VHTST	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q03164	Histone-lysine N-methyltransferase 2A	DEG_SPOP_SBC_1	2810:2814	VHTST	SPOP	0.9894	More...
Q5H9I0	Transcription factor Dp family member 3	DEG_SPOP_SBC_1	29:33	VHTST	SPOP	0.9844	More...
Q9H582	Zinc finger protein 644	DEG_SPOP_SBC_1	377:381	VHTST	SPOP	0.9983	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2574:2578	VHTST	SPOP	0.8934	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3274:3278	VHTST	SPOP	0.9074	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4559:4563	VHTST	SPOP	0.9602	More...
Q9UGC7	Peptide chain release factor 1-like, mitochondrial	DEG_SPOP_SBC_1	214:218	VHTST	SPOP	0.8151	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons