DegronMD

Uniprot ID: Q9HC84

Source protein: Mucin-5B

Source gene: MUC5B

Class: DEG_SPOP_SBC_1

Location: 2574:2578

E3 ligase: SPOP

DEGRON score: 0.8934

ASA_SCORE: 89.7

COIL: 0.7812

CONS_SCORE: 0.2579

DSS_SCORE: 0.6146

HELIX: 0.0236

FCONS_SCORE: 0.9508

RIG_SCORE: 0.7547

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P2571A	TCGA-56-7223	LUSC	TCGA	VHTST	DEG_SPOP_SBC_1	0.25
p.T2570S	TCGA-66-2763	LUSC	TCGA	VHTST	DEG_SPOP_SBC_1	0.2222
p.A2565T	TCGA-A5-A0G1	UCEC	TCGA	VHTST	DEG_SPOP_SBC_1	0.0833
p.P2567S	TCGA-A5-A0G2	UCEC	TCGA	VHTST	DEG_SPOP_SBC_1	0.1389
p.V2574I	TCGA-A6-5661	COAD	TCGA	VHTST	DEG_SPOP_SBC_1	0.7076
p.T2576I	TCGA-AP-A0LM	UCEC	TCGA	VHTST	DEG_SPOP_SBC_1	0.7078
p.H2575P	TCGA-AX-A06F	UCEC	TCGA	VHTST	DEG_SPOP_SBC_1	0.6583
p.S2568F	TCGA-DG-A2KK	CESC	TCGA	VHTST	DEG_SPOP_SBC_1	0.1667
p.S2569F	TCGA-G2-AA3C	BLCA	TCGA	VHTST	DEG_SPOP_SBC_1	0.1944
p.T2578I	TCGA-NJ-A4YP	LUAD	TCGA	VHTST	DEG_SPOP_SBC_1	0.7078
p.S2572F	DO51883	BLCA	ICGC	VHTST	DEG_SPOP_SBC_1	0.2778
p.S2571F	DO51595	CESC	ICGC	VHTST	DEG_SPOP_SBC_1	0.25
p.V2577I	DO8634	COAD	ICGC	VHTST	DEG_SPOP_SBC_1	0.7076
p.M2565I	DO229015	LICA	ICGC	VHTST	DEG_SPOP_SBC_1	0.0833
p.T2585N	DO218922	LUAD	ICGC	VHTST	DEG_SPOP_SBC_1	0.1389
p.T2585N	DO219209	LUSC	ICGC	VHTST	DEG_SPOP_SBC_1	0.1389
p.P2574A	DO26999	LUSC	ICGC	VHTST	DEG_SPOP_SBC_1	0.7503
p.T2573S	DO27620	LUSC	ICGC	VHTST	DEG_SPOP_SBC_1	0.3056
p.H2578P	DO41752	UCEC	ICGC	VHTST	DEG_SPOP_SBC_1	0.7694
p.P2570S	DO41235	UCEC	ICGC	VHTST	DEG_SPOP_SBC_1	0.2222
p.A2568T	DO42472	UCEC	ICGC	VHTST	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q03164	Histone-lysine N-methyltransferase 2A	DEG_SPOP_SBC_1	2810:2814	VHTST	SPOP	0.9894	More...
Q5H9I0	Transcription factor Dp family member 3	DEG_SPOP_SBC_1	29:33	VHTST	SPOP	0.9844	More...
Q9H582	Zinc finger protein 644	DEG_SPOP_SBC_1	377:381	VHTST	SPOP	0.9983	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2574:2578	VHTST	SPOP	0.8934	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3274:3278	VHTST	SPOP	0.9074	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4559:4563	VHTST	SPOP	0.9602	More...
Q9UGC7	Peptide chain release factor 1-like, mitochondrial	DEG_SPOP_SBC_1	214:218	VHTST	SPOP	0.8151	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons