DegronMD

Uniprot ID: Q5H9I0

Source protein: Transcription factor Dp family member 3

Source gene: TFDP3

Class: DEG_SPOP_SBC_1

Location: 29:33

E3 ligase: SPOP

DEGRON score: 0.9844

ASA_SCORE: 68.48

COIL: 0.6904

CONS_SCORE: 0.3534

DSS_SCORE: 0.5029

HELIX: 0.0208

FCONS_SCORE: 1.0409

RIG_SCORE: 0.7578

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V29I	TCGA-DI-A0WH	UCEC	TCGA	VHTST	DEG_SPOP_SBC_1	0.7076
p.V29I	DO43843	UCEC	ICGC	VHTST	DEG_SPOP_SBC_1	0.7076
p.V27L	TCGA-EO-A3B0	UCEC	TCGA	VHTST	DEG_SPOP_SBC_1	0.2778
p.V27L	DO219773	UCEC	ICGC	VHTST	DEG_SPOP_SBC_1	0.2778
p.R25C	TCGA-VS-A9UL	CESC	TCGA	VHTST	DEG_SPOP_SBC_1	0.2222
p.R25C	DO51643	CESC	ICGC	VHTST	DEG_SPOP_SBC_1	0.2222
p.S32T	TCGA-WS-AB45	COAD	TCGA	VHTST	DEG_SPOP_SBC_1	0.6005
p.S32T	DO51734	COAD	ICGC	VHTST	DEG_SPOP_SBC_1	0.6005
p.T23N	DO228900	LICA	ICGC	VHTST	DEG_SPOP_SBC_1	0.1667
p.T23N	DO228952	LICA	ICGC	VHTST	DEG_SPOP_SBC_1	0.1667
p.E20K	DO23942	LUAD	ICGC	VHTST	DEG_SPOP_SBC_1	0.0833
p.N35K	DO228294	MALY	ICGC	VHTST	DEG_SPOP_SBC_1	0.2778
p.H30Y	DO229459	SKCA	ICGC	VHTST	DEG_SPOP_SBC_1	0.6118
p.L42S	SIDM01943	Colorectal Carcinoma	GDSC	VHTST	DEG_SPOP_SBC_1	0.0833
p.V34M	SIDM00958	Chronic Myelogenous Leukemia	GDSC	VHTST	DEG_SPOP_SBC_1	0.3056
p.V34M	ACH-000920	Leukemia	CCLE	VHTST	DEG_SPOP_SBC_1	0.3056
p.V34M	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	VHTST	DEG_SPOP_SBC_1	0.3056
p.V27M	SIDM00364	B-Lymphoblastic Leukemia	GDSC	VHTST	DEG_SPOP_SBC_1	0.2778
p.V27M	SIDM01612	Endometrial Carcinoma	GDSC	VHTST	DEG_SPOP_SBC_1	0.2778
p.V27M	ACH-002059	Leukemia	CCLE	VHTST	DEG_SPOP_SBC_1	0.2778
p.V27M	P30-OHK	haematopoietic_and_lymphoid_tissue	COSMIC	VHTST	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q03164	Histone-lysine N-methyltransferase 2A	DEG_SPOP_SBC_1	2810:2814	VHTST	SPOP	0.9894	More...
Q5H9I0	Transcription factor Dp family member 3	DEG_SPOP_SBC_1	29:33	VHTST	SPOP	0.9844	More...
Q9H582	Zinc finger protein 644	DEG_SPOP_SBC_1	377:381	VHTST	SPOP	0.9983	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2574:2578	VHTST	SPOP	0.8934	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3274:3278	VHTST	SPOP	0.9074	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4559:4563	VHTST	SPOP	0.9602	More...
Q9UGC7	Peptide chain release factor 1-like, mitochondrial	DEG_SPOP_SBC_1	214:218	VHTST	SPOP	0.8151	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons