DegronMD

Uniprot ID: Q9HC84

Source protein: Mucin-5B

Source gene: MUC5B

Class: DEG_SPOP_SBC_1

Location: 4559:4563

E3 ligase: SPOP

DEGRON score: 0.9602

ASA_SCORE: 91.82

COIL: 0.8442

CONS_SCORE: -1000

DSS_SCORE: 0.6052

HELIX: 0.0308

FCONS_SCORE: 1.2942

RIG_SCORE: 0.7636

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T4555A	TCGA-BK-A6W3	UCEC	TCGA	VHTST	DEG_SPOP_SBC_1	0.2222
p.T4555A	SIDM00238	Ovarian Carcinoma	GDSC	VHTST	DEG_SPOP_SBC_1	0.2222
p.T4555A	ACH-000947	Ovarian Cancer	CCLE	VHTST	DEG_SPOP_SBC_1	0.2222
p.T4555A	OVK-18	ovary	COSMIC	VHTST	DEG_SPOP_SBC_1	0.2222
p.A4567D	TCGA-CN-5370	HNSC	TCGA	VHTST	DEG_SPOP_SBC_1	0.2222
p.A4550T	TCGA-XK-AAIW	PRAD	TCGA	VHTST	DEG_SPOP_SBC_1	0.0833
p.V4562A	DO48402	BLCA	ICGC	VHTST	DEG_SPOP_SBC_1	0.6936
p.A4570D	DO15126	HNSC	ICGC	VHTST	DEG_SPOP_SBC_1	0.1389
p.A4553T	DO51407	PRAD	ICGC	VHTST	DEG_SPOP_SBC_1	0.1667
p.S4557F	DO47048	RECA	ICGC	VHTST	DEG_SPOP_SBC_1	0.2778
p.T4558A	DO50076	UCEC	ICGC	VHTST	DEG_SPOP_SBC_1	0.3056
p.T4570S	SIDM00741	Small Cell Lung Carcinoma	GDSC	VHTST	DEG_SPOP_SBC_1	0.1389
p.T4570S	ACH-000431	Lung Cancer	CCLE	VHTST	DEG_SPOP_SBC_1	0.1389
p.T4570S	NCI-H1694	lung	COSMIC	VHTST	DEG_SPOP_SBC_1	0.1389
p.V4559I	SIDM01609	Endometrial Carcinoma	GDSC	VHTST	DEG_SPOP_SBC_1	0.7076
p.V4559I	ACH-000972	Endometrial/Uterine Cancer	CCLE	VHTST	DEG_SPOP_SBC_1	0.7076

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q03164	Histone-lysine N-methyltransferase 2A	DEG_SPOP_SBC_1	2810:2814	VHTST	SPOP	0.9894	More...
Q5H9I0	Transcription factor Dp family member 3	DEG_SPOP_SBC_1	29:33	VHTST	SPOP	0.9844	More...
Q9H582	Zinc finger protein 644	DEG_SPOP_SBC_1	377:381	VHTST	SPOP	0.9983	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2574:2578	VHTST	SPOP	0.8934	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3274:3278	VHTST	SPOP	0.9074	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4559:4563	VHTST	SPOP	0.9602	More...
Q9UGC7	Peptide chain release factor 1-like, mitochondrial	DEG_SPOP_SBC_1	214:218	VHTST	SPOP	0.8151	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons