DegronMD

Uniprot ID: Q9UGC7

Source protein: Peptide chain release factor 1-like, mitochondrial

Source gene: MTRF1L

Class: DEG_SPOP_SBC_1

Location: 214:218

E3 ligase: SPOP

DEGRON score: 0.8151

ASA_SCORE: 31.86

COIL: 0.2578

CONS_SCORE: 0.7459

DSS_SCORE: 0.5335

HELIX: 0.0086

FCONS_SCORE: 1.2116

RIG_SCORE: 0.763

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R213H	TCGA-BR-8487	STAD	TCGA	VHTST	DEG_SPOP_SBC_1	0.3056
p.R213H	DO234462	ESAD	ICGC	VHTST	DEG_SPOP_SBC_1	0.3056
p.R213H	DO47867	STAD	ICGC	VHTST	DEG_SPOP_SBC_1	0.3056
p.R213H	ACH-000533	Rhabdoid	CCLE	VHTST	DEG_SPOP_SBC_1	0.3056
p.T228A	TCGA-CG-5721	STAD	TCGA	VHTST	DEG_SPOP_SBC_1	0.5
p.T228A	DO38192	STAD	ICGC	VHTST	DEG_SPOP_SBC_1	0.5
p.K207N	TCGA-P4-A5EA	KIRP	TCGA	VHTST	DEG_SPOP_SBC_1	0.25
p.K207N	DO48582	KIRP	ICGC	VHTST	DEG_SPOP_SBC_1	0.25
p.V214I	DO229003	COCA	ICGC	VHTST	DEG_SPOP_SBC_1	0.7076
p.V214I	DO229005	COCA	ICGC	VHTST	DEG_SPOP_SBC_1	0.7076
p.V214I	DO228941	LICA	ICGC	VHTST	DEG_SPOP_SBC_1	0.7076
p.V214I	DO231049	LUSC	ICGC	VHTST	DEG_SPOP_SBC_1	0.7076
p.P225T	DO229026	LICA	ICGC	VHTST	DEG_SPOP_SBC_1	0.1389
p.V205M	DO50712	ORCA	ICGC	VHTST	DEG_SPOP_SBC_1	0.0833
p.P225H	ACH-001369	Ovarian Cancer	CCLE	VHTST	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q03164	Histone-lysine N-methyltransferase 2A	DEG_SPOP_SBC_1	2810:2814	VHTST	SPOP	0.9894	More...
Q5H9I0	Transcription factor Dp family member 3	DEG_SPOP_SBC_1	29:33	VHTST	SPOP	0.9844	More...
Q9H582	Zinc finger protein 644	DEG_SPOP_SBC_1	377:381	VHTST	SPOP	0.9983	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2574:2578	VHTST	SPOP	0.8934	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3274:3278	VHTST	SPOP	0.9074	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4559:4563	VHTST	SPOP	0.9602	More...
Q9UGC7	Peptide chain release factor 1-like, mitochondrial	DEG_SPOP_SBC_1	214:218	VHTST	SPOP	0.8151	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons