DegronMD

Uniprot ID: Q9H582

Source protein: Zinc finger protein 644

Source gene: ZNF644

Class: DEG_SPOP_SBC_1

Location: 377:381

E3 ligase: SPOP

DEGRON score: 0.9983

ASA_SCORE: 82.94

COIL: 0.7674

CONS_SCORE: 0.628

DSS_SCORE: 0.4355

HELIX: 0.133

FCONS_SCORE: 1.3261

RIG_SCORE: 0.7307

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D368Y	TCGA-19-5956	GBM	TCGA	VHTST	DEG_SPOP_SBC_1	0.0833
p.D368Y	DO13863	GBM	ICGC	VHTST	DEG_SPOP_SBC_1	0.0833
p.E373Q	TCGA-D5-6536	COAD	TCGA	VHTST	DEG_SPOP_SBC_1	0.2222
p.E373Q	DO8200	COAD	ICGC	VHTST	DEG_SPOP_SBC_1	0.2222
p.K389N	TCGA-EY-A1GI	UCEC	TCGA	VHTST	DEG_SPOP_SBC_1	0.2222
p.K389N	DO41211	UCEC	ICGC	VHTST	DEG_SPOP_SBC_1	0.2222
p.N385S	TCGA-IB-7651	PAAD	TCGA	VHTST	DEG_SPOP_SBC_1	0.2222
p.N385S	DO46657	PAAD	ICGC	VHTST	DEG_SPOP_SBC_1	0.2222
p.P367L	DO228948	LICA	ICGC	VHTST	DEG_SPOP_SBC_1	0.0556
p.P367L	SIDM00232	Kidney Carcinoma	GDSC	VHTST	DEG_SPOP_SBC_1	0.0556
p.P367L	NCC021	kidney	COSMIC	VHTST	DEG_SPOP_SBC_1	0.0556
p.P367T	DO228952	LICA	ICGC	VHTST	DEG_SPOP_SBC_1	0.0556
p.P367T	ACH-000961	Endometrial/Uterine Cancer	CCLE	VHTST	DEG_SPOP_SBC_1	0.0556
p.S384P	SIDM01660	Kidney Carcinoma	GDSC	VHTST	DEG_SPOP_SBC_1	0.25
p.S384P	ACH-000709	Kidney Cancer	CCLE	VHTST	DEG_SPOP_SBC_1	0.25
p.R377H	OVK-18	ovary	COSMIC	VHTST	DEG_SPOP_SBC_1	0.8244

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q03164	Histone-lysine N-methyltransferase 2A	DEG_SPOP_SBC_1	2810:2814	VHTST	SPOP	0.9894	More...
Q5H9I0	Transcription factor Dp family member 3	DEG_SPOP_SBC_1	29:33	VHTST	SPOP	0.9844	More...
Q9H582	Zinc finger protein 644	DEG_SPOP_SBC_1	377:381	VHTST	SPOP	0.9983	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2574:2578	VHTST	SPOP	0.8934	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3274:3278	VHTST	SPOP	0.9074	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4559:4563	VHTST	SPOP	0.9602	More...
Q9UGC7	Peptide chain release factor 1-like, mitochondrial	DEG_SPOP_SBC_1	214:218	VHTST	SPOP	0.8151	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons