DegronMD

Uniprot ID: Q9HC84

Source protein: Mucin-5B

Source gene: MUC5B

Class: DEG_SPOP_SBC_1

Location: 3274:3278

E3 ligase: SPOP

DEGRON score: 0.9074

ASA_SCORE: 96.2

COIL: 0.9132

CONS_SCORE: 0.2732

DSS_SCORE: 0.6366

HELIX: 0.0226

FCONS_SCORE: 0.7781

RIG_SCORE: 0.7463

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T3270S	TCGA-66-2763	LUSC	TCGA	VHTST	DEG_SPOP_SBC_1	0.2222
p.V3274A	TCGA-AD-5900	COAD	TCGA	VHTST	DEG_SPOP_SBC_1	0.5825
p.V3274A	SIDM00842	Colorectal Carcinoma	GDSC	VHTST	DEG_SPOP_SBC_1	0.5825
p.V3274A	SIDM00094	Kidney Carcinoma	GDSC	VHTST	DEG_SPOP_SBC_1	0.5825
p.V3274A	COLO-320-HSR	large_intestine	COSMIC	VHTST	DEG_SPOP_SBC_1	0.5825
p.V3274A	SN12C	kidney	COSMIC	VHTST	DEG_SPOP_SBC_1	0.5825
p.V3277A	DO8514	COAD	ICGC	VHTST	DEG_SPOP_SBC_1	0.6936
p.T3287A	DO222809	COCA	ICGC	VHTST	DEG_SPOP_SBC_1	0.0833
p.T3287A	DO229016	COCA	ICGC	VHTST	DEG_SPOP_SBC_1	0.0833
p.T3287A	DO229003	COCA	ICGC	VHTST	DEG_SPOP_SBC_1	0.0833
p.T3287A	DO229005	COCA	ICGC	VHTST	DEG_SPOP_SBC_1	0.0833
p.M3265I	DO228986	LICA	ICGC	VHTST	DEG_SPOP_SBC_1	0.0833
p.T3273S	DO27620	LUSC	ICGC	VHTST	DEG_SPOP_SBC_1	0.3056
p.T3286M	DO48174	UCEC	ICGC	VHTST	DEG_SPOP_SBC_1	0.1111
p.S3266P	DO42713	UCEC	ICGC	VHTST	DEG_SPOP_SBC_1	0.1111
p.T3264I	SIDM00619	Thyroid Gland Carcinoma	GDSC	VHTST	DEG_SPOP_SBC_1	0.0556
p.T3264I	KMH-2	thyroid	COSMIC	VHTST	DEG_SPOP_SBC_1	0.0556
p.T3273I	SIDM00965	Small Cell Lung Carcinoma	GDSC	VHTST	DEG_SPOP_SBC_1	0.3056
p.T3273I	ACH-000800	Lung Cancer	CCLE	VHTST	DEG_SPOP_SBC_1	0.3056
p.T3273I	NCI-H446	lung	COSMIC	VHTST	DEG_SPOP_SBC_1	0.3056
p.R3288S	SIDM01442	Glioma	GDSC	VHTST	DEG_SPOP_SBC_1	0.0556
p.R3288G	KARPAS-422	haematopoietic_and_lymphoid_tissue	COSMIC	VHTST	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q03164	Histone-lysine N-methyltransferase 2A	DEG_SPOP_SBC_1	2810:2814	VHTST	SPOP	0.9894	More...
Q5H9I0	Transcription factor Dp family member 3	DEG_SPOP_SBC_1	29:33	VHTST	SPOP	0.9844	More...
Q9H582	Zinc finger protein 644	DEG_SPOP_SBC_1	377:381	VHTST	SPOP	0.9983	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2574:2578	VHTST	SPOP	0.8934	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3274:3278	VHTST	SPOP	0.9074	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4559:4563	VHTST	SPOP	0.9602	More...
Q9UGC7	Peptide chain release factor 1-like, mitochondrial	DEG_SPOP_SBC_1	214:218	VHTST	SPOP	0.8151	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons