DegronMD - Q9H582(ZNF644)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R460C	TCGA-06-5416	GBM	TCGA	MIIHQE	LIG_APCC_ABBA_1	467:472	Mutation rewiring degron network	0.1389
p.R460C	TCGA-AP-A056	UCEC	TCGA	MIIHQE	LIG_APCC_ABBA_1	467:472	Mutation rewiring degron network	0.1389
p.R460C	DO10880	GBM	ICGC	MIIHQE	LIG_APCC_ABBA_1	467:472	Mutation rewiring degron network	0.1389
p.R460C	DO43971	UCEC	ICGC	MIIHQE	LIG_APCC_ABBA_1	467:472	Mutation rewiring degron network	0.1389
p.D368Y	TCGA-19-5956	GBM	TCGA	VHTST	DEG_SPOP_SBC_1	377:381	Mutation rewiring degron network	0.0833
p.D368Y	DO13863	GBM	ICGC	VHTST	DEG_SPOP_SBC_1	377:381	Mutation rewiring degron network	0.0833
p.K465N	TCGA-A8-A09A	BRCA	TCGA	MIIHQE	LIG_APCC_ABBA_1	467:472	Mutation rewiring degron network	0.2778
p.K465N	DO2955	BRCA	ICGC	MIIHQE	LIG_APCC_ABBA_1	467:472	Mutation rewiring degron network	0.2778
p.G1059D	TCGA-AA-3663	COAD	TCGA	VRGHLKRLG	DEG_APCC_DBOX_1	1057:1065	Mutation altering degron motif	0.6087
p.G1059D	DO9346	COAD	ICGC	VRGHLKRLG	DEG_APCC_DBOX_1	1057:1065	Mutation altering degron motif	0.6087
p.Q475H	TCGA-AZ-4315	COAD	TCGA	MIIHQE	LIG_APCC_ABBA_1	467:472	Mutation rewiring degron network	0.25
p.Q475H	DO8842	COAD	ICGC	MIIHQE	LIG_APCC_ABBA_1	467:472	Mutation rewiring degron network	0.25
p.R482C	TCGA-B5-A0JY	UCEC	TCGA	MIIHQE	LIG_APCC_ABBA_1	467:472	Mutation rewiring degron network	0.0556
p.R482C	DO8730	COAD	ICGC	MIIHQE	LIG_APCC_ABBA_1	467:472	Mutation rewiring degron network	0.0556
p.R482C	DO43041	UCEC	ICGC	MIIHQE	LIG_APCC_ABBA_1	467:472	Mutation rewiring degron network	0.0556
p.R460H	TCGA-B5-A3FC	UCEC	TCGA	MIIHQE	LIG_APCC_ABBA_1	467:472	Mutation rewiring degron network	0.1389
p.R460H	TCGA-BR-7851	STAD	TCGA	MIIHQE	LIG_APCC_ABBA_1	467:472	Mutation rewiring degron network	0.1389
p.R460H	TCGA-D5-6927	COAD	TCGA	MIIHQE	LIG_APCC_ABBA_1	467:472	Mutation rewiring degron network	0.1389
p.R460H	TCGA-EO-A22U	UCEC	TCGA	MIIHQE	LIG_APCC_ABBA_1	467:472	Mutation rewiring degron network	0.1389
p.R460H	DO10332	COAD	ICGC	MIIHQE	LIG_APCC_ABBA_1	467:472	Mutation rewiring degron network	0.1389
p.R460H	DO232761	PBCA	ICGC	MIIHQE	LIG_APCC_ABBA_1	467:472	Mutation rewiring degron network	0.1389
p.R460H	DO38711	STAD	ICGC	MIIHQE	LIG_APCC_ABBA_1	467:472	Mutation rewiring degron network	0.1389
p.R460H	DO41871	UCEC	ICGC	MIIHQE	LIG_APCC_ABBA_1	467:472	Mutation rewiring degron network	0.1389
p.R460H	DO43755	UCEC	ICGC	MIIHQE	LIG_APCC_ABBA_1	467:472	Mutation rewiring degron network	0.1389
p.E472D	TCGA-D5-6536	COAD	TCGA	MIIHQE	LIG_APCC_ABBA_1	467:472	Mutation altering degron motif	0.5647
p.E472D	DO8200	COAD	ICGC	MIIHQE	LIG_APCC_ABBA_1	467:472	Mutation altering degron motif	0.5647
p.E373Q	TCGA-D5-6536	COAD	TCGA	VHTST	DEG_SPOP_SBC_1	377:381	Mutation rewiring degron network	0.2222
p.E373Q	DO8200	COAD	ICGC	VHTST	DEG_SPOP_SBC_1	377:381	Mutation rewiring degron network	0.2222
p.K389N	TCGA-EY-A1GI	UCEC	TCGA	VHTST	DEG_SPOP_SBC_1	377:381	Mutation substituting flanking lysine	0.2222
p.K389N	DO41211	UCEC	ICGC	VHTST	DEG_SPOP_SBC_1	377:381	Mutation substituting flanking lysine	0.2222
p.N385S	TCGA-IB-7651	PAAD	TCGA	VHTST	DEG_SPOP_SBC_1	377:381	Mutation rewiring degron network	0.2222
p.N385S	DO46657	PAAD	ICGC	VHTST	DEG_SPOP_SBC_1	377:381	Mutation rewiring degron network	0.2222
p.R458Q	DO222762	COCA	ICGC	MIIHQE	LIG_APCC_ABBA_1	467:472	Mutation rewiring degron network	0.0833
p.A1071V	DO233693	GACA	ICGC	VRGHLKRLG	DEG_APCC_DBOX_1	1057:1065	Mutation rewiring degron network	0.1667
p.P367L	DO228948	LICA	ICGC	VHTST	DEG_SPOP_SBC_1	377:381	Mutation rewiring degron network	0.0556
p.P367L	SIDM00232	Kidney Carcinoma	GDSC	VHTST	DEG_SPOP_SBC_1	377:381	Mutation rewiring degron network	0.0556
p.P367L	NCC021	kidney	COSMIC	VHTST	DEG_SPOP_SBC_1	377:381	Mutation rewiring degron network	0.0556
p.P367T	DO228952	LICA	ICGC	VHTST	DEG_SPOP_SBC_1	377:381	Mutation rewiring degron network	0.0556
p.P367T	ACH-000961	Endometrial/Uterine Cancer	CCLE	VHTST	DEG_SPOP_SBC_1	377:381	Mutation rewiring degron network	0.0556
p.H1056N	DO229036	LICA	ICGC	VRGHLKRLG	DEG_APCC_DBOX_1	1057:1065	Mutation rewiring degron network	0.3056
p.H1056N	DO229045	LICA	ICGC	VRGHLKRLG	DEG_APCC_DBOX_1	1057:1065	Mutation rewiring degron network	0.3056
p.I1051N	SIDM01016	T-Lymphoblastic Leukemia	GDSC	VRGHLKRLG	DEG_APCC_DBOX_1	1057:1065	Mutation rewiring degron network	0.1667
p.I1051N	ACH-000995	Leukemia	CCLE	VRGHLKRLG	DEG_APCC_DBOX_1	1057:1065	Mutation rewiring degron network	0.1667
p.I1051N	Jurkat	haematopoietic and lymphoid tissue	COSMIC	VRGHLKRLG	DEG_APCC_DBOX_1	1057:1065	Mutation rewiring degron network	0.1667
p.S384P	SIDM01660	Kidney Carcinoma	GDSC	VHTST	DEG_SPOP_SBC_1	377:381	Mutation rewiring degron network	0.25
p.S384P	ACH-000709	Kidney Cancer	CCLE	VHTST	DEG_SPOP_SBC_1	377:381	Mutation rewiring degron network	0.25
p.R377H	OVK-18	ovary	COSMIC	VHTST	DEG_SPOP_SBC_1	377:381	Mutation altering degron motif	0.8244
p.G471S	HuO-3N1	bone	COSMIC	MIIHQE	LIG_APCC_ABBA_1	467:472	Mutation altering degron motif	0.6993

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZNF644

UniProt ID: Q9H582

Entrez ID: 84146

Protein name: Zinc finger protein 644 (Zinc finger motif enhancer-binding protein 2) (Zep-2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZNF644 in