DegronMD

Uniprot ID: Q9H582

Source protein: Zinc finger protein 644

Source gene: ZNF644

Class: LIG_APCC_ABBA_1

Location: 467:472

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5181

ASA_SCORE: 85.4833

COIL: 0.5475

CONS_SCORE: 0.8876

DSS_SCORE: 0.327

HELIX: 0.1963

FCONS_SCORE: 1.1738

RIG_SCORE: 0.8351

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R460C	TCGA-06-5416	GBM	TCGA	MIIHQE	LIG_APCC_ABBA_1	0.1389
p.R460C	TCGA-AP-A056	UCEC	TCGA	MIIHQE	LIG_APCC_ABBA_1	0.1389
p.R460C	DO10880	GBM	ICGC	MIIHQE	LIG_APCC_ABBA_1	0.1389
p.R460C	DO43971	UCEC	ICGC	MIIHQE	LIG_APCC_ABBA_1	0.1389
p.K465N	TCGA-A8-A09A	BRCA	TCGA	MIIHQE	LIG_APCC_ABBA_1	0.2778
p.K465N	DO2955	BRCA	ICGC	MIIHQE	LIG_APCC_ABBA_1	0.2778
p.Q475H	TCGA-AZ-4315	COAD	TCGA	MIIHQE	LIG_APCC_ABBA_1	0.25
p.Q475H	DO8842	COAD	ICGC	MIIHQE	LIG_APCC_ABBA_1	0.25
p.R482C	TCGA-B5-A0JY	UCEC	TCGA	MIIHQE	LIG_APCC_ABBA_1	0.0556
p.R482C	DO8730	COAD	ICGC	MIIHQE	LIG_APCC_ABBA_1	0.0556
p.R482C	DO43041	UCEC	ICGC	MIIHQE	LIG_APCC_ABBA_1	0.0556
p.R460H	TCGA-B5-A3FC	UCEC	TCGA	MIIHQE	LIG_APCC_ABBA_1	0.1389
p.R460H	TCGA-BR-7851	STAD	TCGA	MIIHQE	LIG_APCC_ABBA_1	0.1389
p.R460H	TCGA-D5-6927	COAD	TCGA	MIIHQE	LIG_APCC_ABBA_1	0.1389
p.R460H	TCGA-EO-A22U	UCEC	TCGA	MIIHQE	LIG_APCC_ABBA_1	0.1389
p.R460H	DO10332	COAD	ICGC	MIIHQE	LIG_APCC_ABBA_1	0.1389
p.R460H	DO232761	PBCA	ICGC	MIIHQE	LIG_APCC_ABBA_1	0.1389
p.R460H	DO38711	STAD	ICGC	MIIHQE	LIG_APCC_ABBA_1	0.1389
p.R460H	DO41871	UCEC	ICGC	MIIHQE	LIG_APCC_ABBA_1	0.1389
p.R460H	DO43755	UCEC	ICGC	MIIHQE	LIG_APCC_ABBA_1	0.1389
p.E472D	TCGA-D5-6536	COAD	TCGA	MIIHQE	LIG_APCC_ABBA_1	0.5647
p.E472D	DO8200	COAD	ICGC	MIIHQE	LIG_APCC_ABBA_1	0.5647
p.R458Q	DO222762	COCA	ICGC	MIIHQE	LIG_APCC_ABBA_1	0.0833
p.G471S	HuO-3N1	bone	COSMIC	MIIHQE	LIG_APCC_ABBA_1	0.6993

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H582	Zinc finger protein 644	LIG_APCC_ABBA_1	467:472	MIIHQE	APC,CDC20,FZR1	0.5181	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons