DegronMD

Uniprot ID: Q9H582

Source protein: Zinc finger protein 644

Source gene: ZNF644

Class: DEG_APCC_DBOX_1

Location: 1057:1065

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5782

ASA_SCORE: 85.7222

COIL: 0.6219

CONS_SCORE: 0.6321

DSS_SCORE: 0.3104

HELIX: 0.18

FCONS_SCORE: 1.0543

RIG_SCORE: 0.7712

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1059D	TCGA-AA-3663	COAD	TCGA	VRGHLKRLG	DEG_APCC_DBOX_1	0.6087
p.G1059D	DO9346	COAD	ICGC	VRGHLKRLG	DEG_APCC_DBOX_1	0.6087
p.A1071V	DO233693	GACA	ICGC	VRGHLKRLG	DEG_APCC_DBOX_1	0.1667
p.H1056N	DO229036	LICA	ICGC	VRGHLKRLG	DEG_APCC_DBOX_1	0.3056
p.H1056N	DO229045	LICA	ICGC	VRGHLKRLG	DEG_APCC_DBOX_1	0.3056
p.I1051N	SIDM01016	T-Lymphoblastic Leukemia	GDSC	VRGHLKRLG	DEG_APCC_DBOX_1	0.1667
p.I1051N	ACH-000995	Leukemia	CCLE	VRGHLKRLG	DEG_APCC_DBOX_1	0.1667
p.I1051N	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	VRGHLKRLG	DEG_APCC_DBOX_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H582	Zinc finger protein 644	DEG_APCC_DBOX_1	1057:1065	VRGHLKRLG	APC,CDC20,FZR1	0.5782	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons