DegronMD - Q5H9I0(TFDP3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G372V	TCGA-13-0760	OV	TCGA	VETPAVE	DEG_SCF_FBW7_2	380:386	Mutation rewiring degron network	0.1111
p.G372V	DO28541	OV	ICGC	VETPAVE	DEG_SCF_FBW7_2	380:386	Mutation rewiring degron network	0.1111
p.G371S	TCGA-22-A5C4	LUSC	TCGA	VETPAVE	DEG_SCF_FBW7_2	380:386	Mutation rewiring degron network	0.0833
p.G371S	DO45446	LUSC	ICGC	VETPAVE	DEG_SCF_FBW7_2	380:386	Mutation rewiring degron network	0.0833
p.P383T	TCGA-44-2668	LUAD	TCGA	VETPAVE	DEG_SCF_FBW7_2	380:386	Mutation altering degron motif	0.7031
p.P383T	DO25232	LUAD	ICGC	VETPAVE	DEG_SCF_FBW7_2	380:386	Mutation altering degron motif	0.7031
p.N101K	TCGA-55-8514	LUAD	TCGA	NQHSYSSPP	CBL_PTK	87:95	Mutation rewiring degron network	0.1667
p.N101K	DO23616	LUAD	ICGC	NQHSYSSPP	CBL_PTK	87:95	Mutation rewiring degron network	0.1667
p.G371D	TCGA-AJ-A3BG	UCEC	TCGA	VETPAVE	DEG_SCF_FBW7_2	380:386	Mutation rewiring degron network	0.0833
p.G371D	DO42633	UCEC	ICGC	VETPAVE	DEG_SCF_FBW7_2	380:386	Mutation rewiring degron network	0.0833
p.G104R	TCGA-BF-A5EQ	SKCM	TCGA	NQHSYSSPP	CBL_PTK	87:95	Mutation rewiring degron network	0.0833
p.G104R	DO219452	SKCM	ICGC	NQHSYSSPP	CBL_PTK	87:95	Mutation rewiring degron network	0.0833
p.G377C	TCGA-CN-A497	HNSC	TCGA	VETPAVE	DEG_SCF_FBW7_2	380:386	Mutation rewiring degron network	0.25
p.G377C	DO218992	HNSC	ICGC	VETPAVE	DEG_SCF_FBW7_2	380:386	Mutation rewiring degron network	0.25
p.G377D	TCGA-D1-A0ZO	UCEC	TCGA	VETPAVE	DEG_SCF_FBW7_2	380:386	Mutation rewiring degron network	0.25
p.G377D	DO41927	UCEC	ICGC	VETPAVE	DEG_SCF_FBW7_2	380:386	Mutation rewiring degron network	0.25
p.D395N	TCGA-D1-A16X	UCEC	TCGA	VETPAVE	DEG_SCF_FBW7_2	380:386	Mutation rewiring degron network	0.0833
p.D395N	DO222498	MELA	ICGC	VETPAVE	DEG_SCF_FBW7_2	380:386	Mutation rewiring degron network	0.0833
p.D395N	DO41799	UCEC	ICGC	VETPAVE	DEG_SCF_FBW7_2	380:386	Mutation rewiring degron network	0.0833
p.P95L	TCGA-D3-A8GM	SKCM	TCGA	NQHSYSSPP	CBL_PTK	87:95	Mutation altering degron motif	0.7582
p.P95L	DO50288	SKCM	ICGC	NQHSYSSPP	CBL_PTK	87:95	Mutation altering degron motif	0.7582
p.E386D	TCGA-D5-6930	COAD	TCGA	VETPAVE	DEG_SCF_FBW7_2	380:386	Mutation altering degron motif	0.6758
p.E386D	DO10550	COAD	ICGC	VETPAVE	DEG_SCF_FBW7_2	380:386	Mutation altering degron motif	0.6758
p.V29I	TCGA-DI-A0WH	UCEC	TCGA	VHTST	DEG_SPOP_SBC_1	29:33	Mutation altering degron motif	0.7076
p.V29I	DO43843	UCEC	ICGC	VHTST	DEG_SPOP_SBC_1	29:33	Mutation altering degron motif	0.7076
p.V380E	TCGA-EC-A1NJ	UCEC	TCGA	VETPAVE	DEG_SCF_FBW7_2	380:386	Mutation altering degron motif	0.7693
p.V380E	DO40855	UCEC	ICGC	VETPAVE	DEG_SCF_FBW7_2	380:386	Mutation altering degron motif	0.7693
p.E105K	TCGA-EE-A29E	SKCM	TCGA	NQHSYSSPP	CBL_PTK	87:95	Mutation rewiring degron network	0.0556
p.E105K	DO37831	SKCM	ICGC	NQHSYSSPP	CBL_PTK	87:95	Mutation rewiring degron network	0.0556
p.V27L	TCGA-EO-A3B0	UCEC	TCGA	VHTST	DEG_SPOP_SBC_1	29:33	Mutation rewiring degron network	0.2778
p.V27L	DO219773	UCEC	ICGC	VHTST	DEG_SPOP_SBC_1	29:33	Mutation rewiring degron network	0.2778
p.R25C	TCGA-VS-A9UL	CESC	TCGA	VHTST	DEG_SPOP_SBC_1	29:33	Mutation rewiring degron network	0.2222
p.R25C	DO51643	CESC	ICGC	VHTST	DEG_SPOP_SBC_1	29:33	Mutation rewiring degron network	0.2222
p.S32T	TCGA-WS-AB45	COAD	TCGA	VHTST	DEG_SPOP_SBC_1	29:33	Mutation altering degron motif	0.6005
p.S32T	DO51734	COAD	ICGC	VHTST	DEG_SPOP_SBC_1	29:33	Mutation altering degron motif	0.6005
p.G372E	TCGA-Z2-AA3V	SKCM	TCGA	VETPAVE	DEG_SCF_FBW7_2	380:386	Mutation rewiring degron network	0.1111
p.G372E	DO51303	SKCM	ICGC	VETPAVE	DEG_SCF_FBW7_2	380:386	Mutation rewiring degron network	0.1111
p.E386K	DO233652	GACA	ICGC	VETPAVE	DEG_SCF_FBW7_2	380:386	Mutation altering degron motif	0.7022
p.T23N	DO228900	LICA	ICGC	VHTST	DEG_SPOP_SBC_1	29:33	Mutation rewiring degron network	0.1667
p.T23N	DO228952	LICA	ICGC	VHTST	DEG_SPOP_SBC_1	29:33	Mutation rewiring degron network	0.1667
p.Q88K	DO229029	LICA	ICGC	NQHSYSSPP	CBL_PTK	87:95	Mutation altering degron motif	0.5833
p.H82Q	DO229038	LICA	ICGC	NQHSYSSPP	CBL_PTK	87:95	Mutation rewiring degron network	0.1944
p.D392E	DO229045	LICA	ICGC	VETPAVE	DEG_SCF_FBW7_2	380:386	Mutation rewiring degron network	0.1667
p.E20K	DO23942	LUAD	ICGC	VHTST	DEG_SPOP_SBC_1	29:33	Mutation rewiring degron network	0.0833
p.N35K	DO228294	MALY	ICGC	VHTST	DEG_SPOP_SBC_1	29:33	Mutation rewiring degron network	0.2778
p.D396N	DO222644	MELA	ICGC	VETPAVE	DEG_SCF_FBW7_2	380:386	Mutation rewiring degron network	0.0556
p.Q88H	DO48940	PBCA	ICGC	NQHSYSSPP	CBL_PTK	87:95	Mutation altering degron motif	0.647
p.H30Y	DO229459	SKCA	ICGC	VHTST	DEG_SPOP_SBC_1	29:33	Mutation altering degron motif	0.6118
p.P79T	DO229208	THCA	ICGC	NQHSYSSPP	CBL_PTK	87:95	Mutation rewiring degron network	0.1111
p.L42S	SIDM01943	Colorectal Carcinoma	GDSC	VHTST	DEG_SPOP_SBC_1	29:33	Mutation rewiring degron network	0.0833
p.V34M	SIDM00958	Chronic Myelogenous Leukemia	GDSC	VHTST	DEG_SPOP_SBC_1	29:33	Mutation rewiring degron network	0.3056
p.V34M	ACH-000920	Leukemia	CCLE	VHTST	DEG_SPOP_SBC_1	29:33	Mutation rewiring degron network	0.3056
p.V34M	CML-T1	haematopoietic and lymphoid tissue	COSMIC	VHTST	DEG_SPOP_SBC_1	29:33	Mutation rewiring degron network	0.3056
p.E386V	SIDM00541	Colorectal Carcinoma	GDSC	VETPAVE	DEG_SCF_FBW7_2	380:386	Mutation altering degron motif	0.7693
p.E386V	ACH-000926	Colon/Colorectal Cancer	CCLE	VETPAVE	DEG_SCF_FBW7_2	380:386	Mutation altering degron motif	0.7693
p.E386V	HT55	large intestine	COSMIC	VETPAVE	DEG_SCF_FBW7_2	380:386	Mutation altering degron motif	0.7693
p.Q99E	SIDM00113	Kidney Carcinoma	GDSC	NQHSYSSPP	CBL_PTK	87:95	Mutation rewiring degron network	0.2222
p.Q99E	ACH-001208	Kidney Cancer	CCLE	NQHSYSSPP	CBL_PTK	87:95	Mutation rewiring degron network	0.2222
p.Q99E	TK10	kidney	COSMIC	NQHSYSSPP	CBL_PTK	87:95	Mutation rewiring degron network	0.2222
p.V27M	SIDM00364	B-Lymphoblastic Leukemia	GDSC	VHTST	DEG_SPOP_SBC_1	29:33	Mutation rewiring degron network	0.2778
p.V27M	SIDM01612	Endometrial Carcinoma	GDSC	VHTST	DEG_SPOP_SBC_1	29:33	Mutation rewiring degron network	0.2778
p.V27M	ACH-002059	Leukemia	CCLE	VHTST	DEG_SPOP_SBC_1	29:33	Mutation rewiring degron network	0.2778
p.V27M	P30-OHK	haematopoietic and lymphoid tissue	COSMIC	VHTST	DEG_SPOP_SBC_1	29:33	Mutation rewiring degron network	0.2778
p.S93A	SIDM00459	B-Cell Non-Hodgkin's Lymphoma	GDSC	NQHSYSSPP	CBL_PTK	87:95	Mutation altering degron motif	0.6477
p.S93A	ACH-001617	Lymphoma	CCLE	NQHSYSSPP	CBL_PTK	87:95	Mutation altering degron motif	0.6477
p.S93A	OCI-LY7	haematopoietic and lymphoid tissue	COSMIC	NQHSYSSPP	CBL_PTK	87:95	Mutation altering degron motif	0.6477
p.G377A	SIDM00863	Burkitt's Lymphoma	GDSC	VETPAVE	DEG_SCF_FBW7_2	380:386	Mutation rewiring degron network	0.25
p.G377A	ACH-001064	Lymphoma	CCLE	VETPAVE	DEG_SCF_FBW7_2	380:386	Mutation rewiring degron network	0.25
p.G377A	EB2	haematopoietic and lymphoid tissue	COSMIC	VETPAVE	DEG_SCF_FBW7_2	380:386	Mutation rewiring degron network	0.25
p.S93L	ACH-000870	Lung Cancer	CCLE	NQHSYSSPP	CBL_PTK	87:95	Mutation altering degron motif	0.6556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TFDP3

UniProt ID: Q5H9I0

Entrez ID: 51270

Protein name: Transcription factor Dp family member 3 (Cancer/testis antigen 30) (CT30) (Hepatocellular carcinoma-associated antigen 661)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TFDP3 in