DegronMD

Uniprot ID: Q5H9I0

Source protein: Transcription factor Dp family member 3

Source gene: TFDP3

Class: DEG_SCF_FBW7_2

Location: 380:386

E3 ligase: FBXW7

DEGRON score: 0.989

ASA_SCORE: 88.3143

COIL: 0.8506

CONS_SCORE: 0.3376

DSS_SCORE: 0.8215

HELIX: 0.1101

FCONS_SCORE: 1.08

RIG_SCORE: 0.663

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G372V	TCGA-13-0760	OV	TCGA	VETPAVE	DEG_SCF_FBW7_2	0.1111
p.G372V	DO28541	OV	ICGC	VETPAVE	DEG_SCF_FBW7_2	0.1111
p.G371S	TCGA-22-A5C4	LUSC	TCGA	VETPAVE	DEG_SCF_FBW7_2	0.0833
p.G371S	DO45446	LUSC	ICGC	VETPAVE	DEG_SCF_FBW7_2	0.0833
p.P383T	TCGA-44-2668	LUAD	TCGA	VETPAVE	DEG_SCF_FBW7_2	0.7031
p.P383T	DO25232	LUAD	ICGC	VETPAVE	DEG_SCF_FBW7_2	0.7031
p.G371D	TCGA-AJ-A3BG	UCEC	TCGA	VETPAVE	DEG_SCF_FBW7_2	0.0833
p.G371D	DO42633	UCEC	ICGC	VETPAVE	DEG_SCF_FBW7_2	0.0833
p.G377C	TCGA-CN-A497	HNSC	TCGA	VETPAVE	DEG_SCF_FBW7_2	0.25
p.G377C	DO218992	HNSC	ICGC	VETPAVE	DEG_SCF_FBW7_2	0.25
p.G377D	TCGA-D1-A0ZO	UCEC	TCGA	VETPAVE	DEG_SCF_FBW7_2	0.25
p.G377D	DO41927	UCEC	ICGC	VETPAVE	DEG_SCF_FBW7_2	0.25
p.D395N	TCGA-D1-A16X	UCEC	TCGA	VETPAVE	DEG_SCF_FBW7_2	0.0833
p.D395N	DO222498	MELA	ICGC	VETPAVE	DEG_SCF_FBW7_2	0.0833
p.D395N	DO41799	UCEC	ICGC	VETPAVE	DEG_SCF_FBW7_2	0.0833
p.E386D	TCGA-D5-6930	COAD	TCGA	VETPAVE	DEG_SCF_FBW7_2	0.6758
p.E386D	DO10550	COAD	ICGC	VETPAVE	DEG_SCF_FBW7_2	0.6758
p.V380E	TCGA-EC-A1NJ	UCEC	TCGA	VETPAVE	DEG_SCF_FBW7_2	0.7693
p.V380E	DO40855	UCEC	ICGC	VETPAVE	DEG_SCF_FBW7_2	0.7693
p.G372E	TCGA-Z2-AA3V	SKCM	TCGA	VETPAVE	DEG_SCF_FBW7_2	0.1111
p.G372E	DO51303	SKCM	ICGC	VETPAVE	DEG_SCF_FBW7_2	0.1111
p.E386K	DO233652	GACA	ICGC	VETPAVE	DEG_SCF_FBW7_2	0.7022
p.D392E	DO229045	LICA	ICGC	VETPAVE	DEG_SCF_FBW7_2	0.1667
p.D396N	DO222644	MELA	ICGC	VETPAVE	DEG_SCF_FBW7_2	0.0556
p.E386V	SIDM00541	Colorectal Carcinoma	GDSC	VETPAVE	DEG_SCF_FBW7_2	0.7693
p.E386V	ACH-000926	Colon/Colorectal Cancer	CCLE	VETPAVE	DEG_SCF_FBW7_2	0.7693
p.E386V	HT55	large_intestine	COSMIC	VETPAVE	DEG_SCF_FBW7_2	0.7693
p.G377A	SIDM00863	Burkitt's Lymphoma	GDSC	VETPAVE	DEG_SCF_FBW7_2	0.25
p.G377A	ACH-001064	Lymphoma	CCLE	VETPAVE	DEG_SCF_FBW7_2	0.25
p.G377A	EB2	haematopoietic_and_lymphoid_tissue	COSMIC	VETPAVE	DEG_SCF_FBW7_2	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VETPAVE

Degron related mutations and impact score

Drug responses associated with TFDP3 mutations

All proteins holding degron of VETPAVE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5H9I0	Transcription factor Dp family member 3	DEG_SCF_FBW7_2	380:386	VETPAVE	FBXW7	0.989	More...