DegronMD

Uniprot ID: Q5H9I0

Source protein: Transcription factor Dp family member 3

Source gene: TFDP3

Class: CBL_PTK

Location: 87:95

E3 ligase: CBL

DEGRON score: 0.9091

ASA_SCORE: 77.1111

COIL: 0.8559

CONS_SCORE: 0.2932

DSS_SCORE: 0.654

HELIX: 0.0872

FCONS_SCORE: 0.8619

RIG_SCORE: 0.5885

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N101K	TCGA-55-8514	LUAD	TCGA	NQHSYSSPP	CBL_PTK	0.1667
p.N101K	DO23616	LUAD	ICGC	NQHSYSSPP	CBL_PTK	0.1667
p.G104R	TCGA-BF-A5EQ	SKCM	TCGA	NQHSYSSPP	CBL_PTK	0.0833
p.G104R	DO219452	SKCM	ICGC	NQHSYSSPP	CBL_PTK	0.0833
p.P95L	TCGA-D3-A8GM	SKCM	TCGA	NQHSYSSPP	CBL_PTK	0.7582
p.P95L	DO50288	SKCM	ICGC	NQHSYSSPP	CBL_PTK	0.7582
p.E105K	TCGA-EE-A29E	SKCM	TCGA	NQHSYSSPP	CBL_PTK	0.0556
p.E105K	DO37831	SKCM	ICGC	NQHSYSSPP	CBL_PTK	0.0556
p.Q88K	DO229029	LICA	ICGC	NQHSYSSPP	CBL_PTK	0.5833
p.H82Q	DO229038	LICA	ICGC	NQHSYSSPP	CBL_PTK	0.1944
p.Q88H	DO48940	PBCA	ICGC	NQHSYSSPP	CBL_PTK	0.647
p.P79T	DO229208	THCA	ICGC	NQHSYSSPP	CBL_PTK	0.1111
p.Q99E	SIDM00113	Kidney Carcinoma	GDSC	NQHSYSSPP	CBL_PTK	0.2222
p.Q99E	ACH-001208	Kidney Cancer	CCLE	NQHSYSSPP	CBL_PTK	0.2222
p.Q99E	TK10	kidney	COSMIC	NQHSYSSPP	CBL_PTK	0.2222
p.S93A	SIDM00459	B-Cell Non-Hodgkin's Lymphoma	GDSC	NQHSYSSPP	CBL_PTK	0.6477
p.S93A	ACH-001617	Lymphoma	CCLE	NQHSYSSPP	CBL_PTK	0.6477
p.S93A	OCI-LY7	haematopoietic_and_lymphoid_tissue	COSMIC	NQHSYSSPP	CBL_PTK	0.6477
p.S93L	ACH-000870	Lung Cancer	CCLE	NQHSYSSPP	CBL_PTK	0.6556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5H9I0	Transcription factor Dp family member 3	CBL_PTK	87:95	NQHSYSSPP	CBL	0.9091	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons