DegronMD

Uniprot ID: Q03164

Source protein: Histone-lysine N-methyltransferase 2A

Source gene: KMT2A

Class: DEG_APCC_DBOX_1

Location: 2203:2211

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5657

ASA_SCORE: 112.0111

COIL: 0.894

CONS_SCORE: 0.3633

DSS_SCORE: 0.6718

HELIX: 0.0809

FCONS_SCORE: 0.9389

RIG_SCORE: 0.7109

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M2216V	TCGA-BR-4184	STAD	TCGA	QRSKLRIMS	DEG_APCC_DBOX_1	0.1944
p.R2221G	DO8487	COAD	ICGC	QRSKLRIMS	DEG_APCC_DBOX_1	0.0556
p.R2194H	DO223044	ESCA	ICGC	QRSKLRIMS	DEG_APCC_DBOX_1	0.0833
p.P2211S	DO49035	HNSC	ICGC	QRSKLRIMS	DEG_APCC_DBOX_1	0.6752
p.A2202S	DO229035	LICA	ICGC	QRSKLRIMS	DEG_APCC_DBOX_1	0.3056
p.V2208G	DO43971	UCEC	ICGC	QRSKLRIMS	DEG_APCC_DBOX_1	0.7532
p.R2207W	SIDM00217	Colorectal Carcinoma	GDSC	QRSKLRIMS	DEG_APCC_DBOX_1	0.8634
p.R2207W	ACH-000999	Colon/Colorectal Cancer	CCLE	QRSKLRIMS	DEG_APCC_DBOX_1	0.8634
p.R2207W	SNU-1040	large_intestine	COSMIC	QRSKLRIMS	DEG_APCC_DBOX_1	0.8634
p.R2204W	SNU-1040	large_intestine	COSMIC	QRSKLRIMS	DEG_APCC_DBOX_1	0.8634

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q03164	Histone-lysine N-methyltransferase 2A	DEG_APCC_DBOX_1	2203:2211	QRSKLRIMS	APC,CDC20,FZR1	0.5657	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons