DegronMD

Uniprot ID: Q03164

Source protein: Histone-lysine N-methyltransferase 2A

Source gene: KMT2A

Class: DEG_SCF_TRCP1_1

Location: 940:946

E3 ligase: BTRC

DEGRON score: 0.9841

ASA_SCORE: 78.5

COIL: 0.8619

CONS_SCORE: 0.3416

DSS_SCORE: 0.4857

HELIX: 0.0279

FCONS_SCORE: 0.9077

RIG_SCORE: 0.6638

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T953A	TCGA-B5-A1MX	UCEC	TCGA	DSGTDIT	DEG_SCF_TRCP1_1	0.1389
p.T953A	DO41999	UCEC	ICGC	DSGTDIT	DEG_SCF_TRCP1_1	0.1389
p.S936Y	TCGA-D1-A16X	UCEC	TCGA	DSGTDIT	DEG_SCF_TRCP1_1	0.2222
p.S936Y	DO41799	UCEC	ICGC	DSGTDIT	DEG_SCF_TRCP1_1	0.2222
p.S938L	TCGA-D9-A3Z1	SKCM	TCGA	DSGTDIT	DEG_SCF_TRCP1_1	0.2778
p.S938L	DO38105	SKCM	ICGC	DSGTDIT	DEG_SCF_TRCP1_1	0.2778
p.L950I	TCGA-ER-A19G	SKCM	TCGA	DSGTDIT	DEG_SCF_TRCP1_1	0.2222
p.L950I	DO47284	SKCM	ICGC	DSGTDIT	DEG_SCF_TRCP1_1	0.2222
p.R933W	DO222955	BTCA	ICGC	DSGTDIT	DEG_SCF_TRCP1_1	0.1389
p.R933W	SIDM00395	Neuroblastoma	GDSC	DSGTDIT	DEG_SCF_TRCP1_1	0.1389
p.R933W	ACH-000099	Neuroblastoma	CCLE	DSGTDIT	DEG_SCF_TRCP1_1	0.1389
p.R933W	SIMA	autonomic_ganglia	COSMIC	DSGTDIT	DEG_SCF_TRCP1_1	0.1389
p.G951W	DO233641	GACA	ICGC	DSGTDIT	DEG_SCF_TRCP1_1	0.1944
p.A955T	DO50912	LICA	ICGC	DSGTDIT	DEG_SCF_TRCP1_1	0.0833
p.K934N	SIDM01007	T-Lymphoblastic Leukemia	GDSC	DSGTDIT	DEG_SCF_TRCP1_1	0.2778
p.K934N	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	DSGTDIT	DEG_SCF_TRCP1_1	0.2778
p.S947Y	SIDM01263	T-Lymphoblastic Leukemia	GDSC	DSGTDIT	DEG_SCF_TRCP1_1	0.3056
p.S941F	ACH-000836	Head and Neck Cancer	CCLE	DSGTDIT	DEG_SCF_TRCP1_1	0.7982

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q03164	Histone-lysine N-methyltransferase 2A	DEG_SCF_TRCP1_1	940:946	DSGTDIT	BTRC	0.9841	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons