DegronMD

Uniprot ID: Q03164

Source protein: Histone-lysine N-methyltransferase 2A

Source gene: KMT2A

Class: DEG_SCF_FBW7_1

Location: 256:263

E3 ligase: FBXW7

DEGRON score: 0.9485

ASA_SCORE: 88.1625

COIL: 0.8033

CONS_SCORE: 0.3387

DSS_SCORE: 0.5269

HELIX: 0.1184

FCONS_SCORE: 0.9592

RIG_SCORE: 0.731

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K254N	TCGA-19-5956	GBM	TCGA	IKRTPSAT	DEG_SCF_FBW7_1	0.2778
p.K254N	DO13863	GBM	ICGC	IKRTPSAT	DEG_SCF_FBW7_1	0.2778
p.K246N	TCGA-AP-A051	UCEC	TCGA	IKRTPSAT	DEG_SCF_FBW7_1	0.1667
p.K246N	DO42673	UCEC	ICGC	IKRTPSAT	DEG_SCF_FBW7_1	0.1667
p.K254Q	TCGA-AX-A0J0	UCEC	TCGA	IKRTPSAT	DEG_SCF_FBW7_1	0.2778
p.K254Q	DO41133	UCEC	ICGC	IKRTPSAT	DEG_SCF_FBW7_1	0.2778
p.S261F	TCGA-GC-A6I1	BLCA	TCGA	IKRTPSAT	DEG_SCF_FBW7_1	0.7982
p.S261F	DO49770	BLCA	ICGC	IKRTPSAT	DEG_SCF_FBW7_1	0.7982
p.I256N	DO234230	ESAD	ICGC	IKRTPSAT	DEG_SCF_FBW7_1	0.728
p.I256N	RPMI-2650	upper_aerodigestive_tract	COSMIC	IKRTPSAT	DEG_SCF_FBW7_1	0.728

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q03164	Histone-lysine N-methyltransferase 2A	DEG_SCF_FBW7_1	256:263	IKRTPSAT	FBXW7	0.9485	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons