DegronMD

Uniprot ID: Q03164

Source protein: Histone-lysine N-methyltransferase 2A

Source gene: KMT2A

Class: DEG_ODPH_VHL_1

Location: 3243:3254

E3 ligase: VHL

DEGRON score: 0.5876

ASA_SCORE: 87.2583

COIL: 0.8577

CONS_SCORE: 0.4364

DSS_SCORE: 0.4252

HELIX: 0.0372

FCONS_SCORE: 1.1933

RIG_SCORE: 0.7229

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S3253Y	TCGA-A5-A2K5	UCEC	TCGA	IAPSDVVSNMTL	DEG_ODPH_VHL_1	0.712
p.S3253Y	TCGA-AP-A1E0	UCEC	TCGA	IAPSDVVSNMTL	DEG_ODPH_VHL_1	0.712
p.P3243H	TCGA-AJ-A3EL	UCEC	TCGA	IAPSDVVSNMTL	DEG_ODPH_VHL_1	0.7694
p.K3233N	TCGA-AX-A06F	UCEC	TCGA	IAPSDVVSNMTL	DEG_ODPH_VHL_1	0.1667
p.S3240C	TCGA-XF-A9T8	BLCA	TCGA	IAPSDVVSNMTL	DEG_ODPH_VHL_1	0.25
p.P3245H	DO219758	CESC	ICGC	IAPSDVVSNMTL	DEG_ODPH_VHL_1	0.7694
p.R3250I	DO7801	COAD	ICGC	IAPSDVVSNMTL	DEG_ODPH_VHL_1	0.8102
p.R3250I	DO222798	COCA	ICGC	IAPSDVVSNMTL	DEG_ODPH_VHL_1	0.8102
p.R3242Q	DO234239	ESAD	ICGC	IAPSDVVSNMTL	DEG_ODPH_VHL_1	0.3056
p.A3261S	DO229041	LICA	ICGC	IAPSDVVSNMTL	DEG_ODPH_VHL_1	0.1389
p.A3261T	DO33091	PACA	ICGC	IAPSDVVSNMTL	DEG_ODPH_VHL_1	0.1389
p.F3258L	DO36394	READ	ICGC	IAPSDVVSNMTL	DEG_ODPH_VHL_1	0.2222
p.S3240Y	DO43025	UCEC	ICGC	IAPSDVVSNMTL	DEG_ODPH_VHL_1	0.25
p.T3242A	SIDM00845	Burkitt's Lymphoma	GDSC	IAPSDVVSNMTL	DEG_ODPH_VHL_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q03164	Histone-lysine N-methyltransferase 2A	DEG_ODPH_VHL_1	3243:3254	IAPSDVVSNMTL	VHL	0.5876	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons