DegronMD

Uniprot ID: Q9Y5A7

Source protein: NEDD8 ultimate buster 1

Source gene: NUB1

Class: DEG_SPOP_SBC_1

Location: 556:560

E3 ligase: SPOP

DEGRON score: 0.9912

ASA_SCORE: 79.2

COIL: 0.9348

CONS_SCORE: 0.3618

DSS_SCORE: 0.8614

HELIX: 0.0518

FCONS_SCORE: 1.0396

RIG_SCORE: 0.4916

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L550I	TCGA-CV-7261	HNSC	TCGA	AGTSS	DEG_SPOP_SBC_1	0.1667
p.L550I	DO15062	HNSC	ICGC	AGTSS	DEG_SPOP_SBC_1	0.1667
p.P559T	TCGA-DK-A3IN	BLCA	TCGA	AGTSS	DEG_SPOP_SBC_1	0.7031
p.P559T	DO455	BLCA	ICGC	AGTSS	DEG_SPOP_SBC_1	0.7031
p.G554E	TCGA-EE-A182	SKCM	TCGA	AGTSS	DEG_SPOP_SBC_1	0.2778
p.G554E	DO37814	SKCM	ICGC	AGTSS	DEG_SPOP_SBC_1	0.2778
p.E566Q	TCGA-HD-7229	HNSC	TCGA	AGTSS	DEG_SPOP_SBC_1	0.1667
p.E566Q	DO15479	HNSC	ICGC	AGTSS	DEG_SPOP_SBC_1	0.1667
p.S564L	DO222817	BTCA	ICGC	AGTSS	DEG_SPOP_SBC_1	0.2222
p.Q548R	DO35242	PACA	ICGC	AGTSS	DEG_SPOP_SBC_1	0.1111
p.L563R	SIDM00370	T-Lymphoblastic Leukemia	GDSC	AGTSS	DEG_SPOP_SBC_1	0.25
p.L563R	ACH-000197	Leukemia	CCLE	AGTSS	DEG_SPOP_SBC_1	0.25
p.A547S	SIDM01129	Small Cell Lung Carcinoma	GDSC	AGTSS	DEG_SPOP_SBC_1	0.0833
p.A547S	ACH-000816	Lung Cancer	CCLE	AGTSS	DEG_SPOP_SBC_1	0.0833
p.A547S	NCI-H524	lung	COSMIC	AGTSS	DEG_SPOP_SBC_1	0.0833
p.A547T	SIDM00596	Endometrial Carcinoma	GDSC	AGTSS	DEG_SPOP_SBC_1	0.0833
p.A547T	SIDM01133	Other Solid Cancers	GDSC	AGTSS	DEG_SPOP_SBC_1	0.0833
p.A547T	ACH-001517	Endometrial/Uterine Cancer	CCLE	AGTSS	DEG_SPOP_SBC_1	0.0833
p.A547T	ACH-002177	Lung Cancer	CCLE	AGTSS	DEG_SPOP_SBC_1	0.0833
p.A547T	NCI-H835	lung	COSMIC	AGTSS	DEG_SPOP_SBC_1	0.0833
p.A547T	HEC-1	endometrium	COSMIC	AGTSS	DEG_SPOP_SBC_1	0.0833
p.P562L	SIDM01709	Melanoma	GDSC	AGTSS	DEG_SPOP_SBC_1	0.2778
p.P562L	ACH-000275	Non-Cancerous	CCLE	AGTSS	DEG_SPOP_SBC_1	0.2778
p.E565K	SNU-81	large_intestine	COSMIC	AGTSS	DEG_SPOP_SBC_1	0.1944
p.T550M	SNU-175	large_intestine	COSMIC	AGTSS	DEG_SPOP_SBC_1	0.1667
p.T560M	SNU-175	large_intestine	COSMIC	AGTSS	DEG_SPOP_SBC_1	0.7423

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60244	Mediator of RNA polymerase II transcription subunit 14	DEG_SPOP_SBC_1	1147:1151	AGTSS	SPOP	0.9972	More...
O95073	Fibrinogen silencer-binding protein	DEG_SPOP_SBC_1	134:138	AGTSS	SPOP	0.9917	More...
O95249	Golgi SNAP receptor complex member 1	DEG_SPOP_SBC_1	3:7	AGTSS	SPOP	0.9984	More...
P16070	CD44 antigen	DEG_SPOP_SBC_1	265:269	AGTSS	SPOP	0.9527	More...
P82094	TATA element modulatory factor	DEG_SPOP_SBC_1	166:170	AGTSS	SPOP	0.9993	More...
Q03164	Histone-lysine N-methyltransferase 2A	DEG_SPOP_SBC_1	724:728	AGTSS	SPOP	0.999	More...
Q5VT06	Centrosome-associated protein 350	DEG_SPOP_SBC_1	1271:1275	AGTSS	SPOP	0.9877	More...
Q6ZP82	Coiled-coil domain-containing protein 141	DEG_SPOP_SBC_1	1253:1257	AGTSS	SPOP	0.9861	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	3117:3121	AGTSS	SPOP	0.9982	More...
Q8TEH3	DENN domain-containing protein 1A	DEG_SPOP_SBC_1	775:779	AGTSS	SPOP	0.8732	More...
Q8WV16	DDB1- and CUL4-associated factor 4	DEG_SPOP_SBC_1	58:62	AGTSS	SPOP	0.9954	More...
Q99990	Transcription cofactor vestigial-like protein 1	DEG_SPOP_SBC_1	137:141	AGTSS	SPOP	0.8905	More...
Q9HCC9	Lateral signaling target protein 2 homolog	DEG_SPOP_SBC_1	474:478	AGTSS	SPOP	0.7998	More...
Q9HCR9	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	DEG_SPOP_SBC_1	56:60	AGTSS	SPOP	0.8678	More...
Q9P0V3	SH3 domain-binding protein 4	DEG_SPOP_SBC_1	197:201	AGTSS	SPOP	0.9517	More...
Q9P212	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	DEG_SPOP_SBC_1	1162:1166	AGTSS	SPOP	0.9841	More...
Q9Y572	Receptor-interacting serine/threonine-protein kinase 3	DEG_SPOP_SBC_1	385:389	AGTSS	SPOP	0.9713	More...
Q9Y5A7	NEDD8 ultimate buster 1	DEG_SPOP_SBC_1	556:560	AGTSS	SPOP	0.9912	More...
Q5VWJ9	Sorting nexin-30	DEG_SPOP_SBC_1	63:67	AGTSS	SPOP	0.9979	More...
Q5JYT7	Uncharacterized protein KIAA1755	DEG_SPOP_SBC_1	294:298	AGTSS	SPOP	0.9974	More...
Q8N4B5	Proline-rich protein 18	DEG_SPOP_SBC_1	119:123	AGTSS	SPOP	0.9888	More...
Q9H6K5	Proline-rich protein 36	DEG_SPOP_SBC_1	83:87	AGTSS	SPOP	0.9884	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AGTSS

Degron related mutations and impact score

Drug responses associated with NUB1 mutations

All proteins holding degron of AGTSS