DegronMD - Q99990(VGLL1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P151S	TCGA-22-4594	LUSC	TCGA	AGTSS	DEG_SPOP_SBC_1	137:141	Mutation rewiring degron network	0.0556
p.P151S	DO27476	LUSC	ICGC	AGTSS	DEG_SPOP_SBC_1	137:141	Mutation rewiring degron network	0.0556
p.T139I	TCGA-23-2641	OV	TCGA	AGTSS	DEG_SPOP_SBC_1	137:141	Mutation altering degron motif	0.7078
p.T139I	DO31574	OV	ICGC	AGTSS	DEG_SPOP_SBC_1	137:141	Mutation altering degron motif	0.7078
p.P161A	TCGA-2Y-A9H9	LIHC	TCGA	KREPLLSLL	DEG_APCC_DBOX_1	164:172	Mutation rewiring degron network	0.25
p.P161A	DO219537	LIHC	ICGC	KREPLLSLL	DEG_APCC_DBOX_1	164:172	Mutation rewiring degron network	0.25
p.P144H	TCGA-49-4488	LUAD	TCGA	AGTSS	DEG_SPOP_SBC_1	137:141	Mutation rewiring degron network	0.25
p.P144H	DO24750	LUAD	ICGC	AGTSS	DEG_SPOP_SBC_1	137:141	Mutation rewiring degron network	0.25
p.R180S	TCGA-56-7823	LUSC	TCGA	KREPLLSLL	DEG_APCC_DBOX_1	164:172	Mutation rewiring degron network	0.1111
p.R180S	DO223721	LUSC	ICGC	KREPLLSLL	DEG_APCC_DBOX_1	164:172	Mutation rewiring degron network	0.1111
p.D162N	TCGA-77-7338	LUSC	TCGA	KREPLLSLL	DEG_APCC_DBOX_1	164:172	Mutation rewiring degron network	0.2778
p.D162N	DO26421	LUSC	ICGC	KREPLLSLL	DEG_APCC_DBOX_1	164:172	Mutation rewiring degron network	0.2778
p.L171F	TCGA-AP-A051	UCEC	TCGA	KREPLLSLL	DEG_APCC_DBOX_1	164:172	Mutation altering degron motif	0.6981
p.L171F	DO42673	UCEC	ICGC	KREPLLSLL	DEG_APCC_DBOX_1	164:172	Mutation altering degron motif	0.6981
p.P144T	TCGA-AP-A0LM	UCEC	TCGA	AGTSS	DEG_SPOP_SBC_1	137:141	Mutation rewiring degron network	0.25
p.P144T	DO43306	UCEC	ICGC	AGTSS	DEG_SPOP_SBC_1	137:141	Mutation rewiring degron network	0.25
p.R165C	TCGA-AX-A0J1	UCEC	TCGA	KREPLLSLL	DEG_APCC_DBOX_1	164:172	Mutation altering degron motif	0.8301
p.R165C	TCGA-Q1-A5R2	CESC	TCGA	KREPLLSLL	DEG_APCC_DBOX_1	164:172	Mutation altering degron motif	0.8301
p.R165C	DO49003	CESC	ICGC	KREPLLSLL	DEG_APCC_DBOX_1	164:172	Mutation altering degron motif	0.8301
p.R165C	DO41199	UCEC	ICGC	KREPLLSLL	DEG_APCC_DBOX_1	164:172	Mutation altering degron motif	0.8301
p.R165C	SIDM00153	T-Lymphoblastic Leukemia	GDSC	KREPLLSLL	DEG_APCC_DBOX_1	164:172	Mutation altering degron motif	0.8301
p.R165C	ACH-000964	Leukemia	CCLE	KREPLLSLL	DEG_APCC_DBOX_1	164:172	Mutation altering degron motif	0.8301
p.G145D	TCGA-B5-A3FC	UCEC	TCGA	AGTSS	DEG_SPOP_SBC_1	137:141	Mutation rewiring degron network	0.2222
p.G145D	DO41871	UCEC	ICGC	AGTSS	DEG_SPOP_SBC_1	137:141	Mutation rewiring degron network	0.2222
p.G128V	TCGA-BS-A0V4	UCEC	TCGA	AGTSS	DEG_SPOP_SBC_1	137:141	Mutation rewiring degron network	0.0833
p.G128V	DO42969	UCEC	ICGC	AGTSS	DEG_SPOP_SBC_1	137:141	Mutation rewiring degron network	0.0833
p.P151H	TCGA-FW-A5DY	SKCM	TCGA	AGTSS	DEG_SPOP_SBC_1	137:141	Mutation rewiring degron network	0.0556
p.P151H	DO47257	SKCM	ICGC	AGTSS	DEG_SPOP_SBC_1	137:141	Mutation rewiring degron network	0.0556
p.L172I	TCGA-HU-A4GN	STAD	TCGA	KREPLLSLL	DEG_APCC_DBOX_1	164:172	Mutation altering degron motif	0.6063
p.L172I	DO47833	STAD	ICGC	KREPLLSLL	DEG_APCC_DBOX_1	164:172	Mutation altering degron motif	0.6063
p.Q174K	DO10486	COAD	ICGC	KREPLLSLL	DEG_APCC_DBOX_1	164:172	Mutation rewiring degron network	0.2778
p.Q174K	SIDM01019	Acute Myeloid Leukemia	GDSC	KREPLLSLL	DEG_APCC_DBOX_1	164:172	Mutation rewiring degron network	0.2778
p.Q174K	ACH-002258	Leukemia	CCLE	KREPLLSLL	DEG_APCC_DBOX_1	164:172	Mutation rewiring degron network	0.2778
p.Q174K	KMOE-2	haematopoietic and lymphoid tissue	COSMIC	KREPLLSLL	DEG_APCC_DBOX_1	164:172	Mutation rewiring degron network	0.2778
p.R180L	DO228986	LICA	ICGC	KREPLLSLL	DEG_APCC_DBOX_1	164:172	Mutation rewiring degron network	0.1111
p.A137S	DO229022	LICA	ICGC	AGTSS	DEG_SPOP_SBC_1	137:141	Mutation altering degron motif	0.7588
p.G163V	DO232761	PBCA	ICGC	KREPLLSLL	DEG_APCC_DBOX_1	164:172	Mutation rewiring degron network	0.3056
p.F150L	SIDM00697	Small Cell Lung Carcinoma	GDSC	AGTSS	DEG_SPOP_SBC_1	137:141	Mutation rewiring degron network	0.0833
p.F150L	ACH-000830	Lung Cancer	CCLE	AGTSS	DEG_SPOP_SBC_1	137:141	Mutation rewiring degron network	0.0833
p.F150L	NCI-H1436	lung	COSMIC	AGTSS	DEG_SPOP_SBC_1	137:141	Mutation rewiring degron network	0.0833
p.S141F	SIDM00221	Melanoma	GDSC	AGTSS	DEG_SPOP_SBC_1	137:141	Mutation altering degron motif	0.7982
p.S141F	ACH-002388	Skin Cancer	CCLE	AGTSS	DEG_SPOP_SBC_1	137:141	Mutation altering degron motif	0.7982
p.A137V	ACH-001369	Ovarian Cancer	CCLE	AGTSS	DEG_SPOP_SBC_1	137:141	Mutation altering degron motif	0.5825

DegronMD: protein-targeted degradation, mutation and drug response to degrons

VGLL1

UniProt ID: Q99990

Entrez ID: 51442

Protein name: Transcription cofactor vestigial-like protein 1 (Vgl-1) (Protein TONDU)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for VGLL1 in