DegronMD

Uniprot ID: Q99990

Source protein: Transcription cofactor vestigial-like protein 1

Source gene: VGLL1

Class: DEG_APCC_DBOX_1

Location: 164:172

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8471

ASA_SCORE: 57.7889

COIL: 0.5547

CONS_SCORE: 0.6451

DSS_SCORE: 0.6468

HELIX: 0.3599

FCONS_SCORE: 1.1036

RIG_SCORE: 0.7339

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P161A	TCGA-2Y-A9H9	LIHC	TCGA	KREPLLSLL	DEG_APCC_DBOX_1	0.25
p.P161A	DO219537	LIHC	ICGC	KREPLLSLL	DEG_APCC_DBOX_1	0.25
p.R180S	TCGA-56-7823	LUSC	TCGA	KREPLLSLL	DEG_APCC_DBOX_1	0.1111
p.R180S	DO223721	LUSC	ICGC	KREPLLSLL	DEG_APCC_DBOX_1	0.1111
p.D162N	TCGA-77-7338	LUSC	TCGA	KREPLLSLL	DEG_APCC_DBOX_1	0.2778
p.D162N	DO26421	LUSC	ICGC	KREPLLSLL	DEG_APCC_DBOX_1	0.2778
p.L171F	TCGA-AP-A051	UCEC	TCGA	KREPLLSLL	DEG_APCC_DBOX_1	0.6981
p.L171F	DO42673	UCEC	ICGC	KREPLLSLL	DEG_APCC_DBOX_1	0.6981
p.R165C	TCGA-AX-A0J1	UCEC	TCGA	KREPLLSLL	DEG_APCC_DBOX_1	0.8301
p.R165C	TCGA-Q1-A5R2	CESC	TCGA	KREPLLSLL	DEG_APCC_DBOX_1	0.8301
p.R165C	DO49003	CESC	ICGC	KREPLLSLL	DEG_APCC_DBOX_1	0.8301
p.R165C	DO41199	UCEC	ICGC	KREPLLSLL	DEG_APCC_DBOX_1	0.8301
p.R165C	SIDM00153	T-Lymphoblastic Leukemia	GDSC	KREPLLSLL	DEG_APCC_DBOX_1	0.8301
p.R165C	ACH-000964	Leukemia	CCLE	KREPLLSLL	DEG_APCC_DBOX_1	0.8301
p.L172I	TCGA-HU-A4GN	STAD	TCGA	KREPLLSLL	DEG_APCC_DBOX_1	0.6063
p.L172I	DO47833	STAD	ICGC	KREPLLSLL	DEG_APCC_DBOX_1	0.6063
p.Q174K	DO10486	COAD	ICGC	KREPLLSLL	DEG_APCC_DBOX_1	0.2778
p.Q174K	SIDM01019	Acute Myeloid Leukemia	GDSC	KREPLLSLL	DEG_APCC_DBOX_1	0.2778
p.Q174K	ACH-002258	Leukemia	CCLE	KREPLLSLL	DEG_APCC_DBOX_1	0.2778
p.Q174K	KMOE-2	haematopoietic_and_lymphoid_tissue	COSMIC	KREPLLSLL	DEG_APCC_DBOX_1	0.2778
p.R180L	DO228986	LICA	ICGC	KREPLLSLL	DEG_APCC_DBOX_1	0.1111
p.G163V	DO232761	PBCA	ICGC	KREPLLSLL	DEG_APCC_DBOX_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q99990	Transcription cofactor vestigial-like protein 1	DEG_APCC_DBOX_1	164:172	KREPLLSLL	APC,CDC20,FZR1	0.8471	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons