DegronMD - Q9Y5A7(NUB1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L550I	TCGA-CV-7261	HNSC	TCGA	AGTSS	DEG_SPOP_SBC_1	556:560	Mutation rewiring degron network	0.1667
p.L550I	DO15062	HNSC	ICGC	AGTSS	DEG_SPOP_SBC_1	556:560	Mutation rewiring degron network	0.1667
p.P559T	TCGA-DK-A3IN	BLCA	TCGA	AGTSS	DEG_SPOP_SBC_1	556:560	Mutation altering degron motif	0.7031
p.P559T	DO455	BLCA	ICGC	AGTSS	DEG_SPOP_SBC_1	556:560	Mutation altering degron motif	0.7031
p.G554E	TCGA-EE-A182	SKCM	TCGA	AGTSS	DEG_SPOP_SBC_1	556:560	Mutation rewiring degron network	0.2778
p.G554E	DO37814	SKCM	ICGC	AGTSS	DEG_SPOP_SBC_1	556:560	Mutation rewiring degron network	0.2778
p.E566Q	TCGA-HD-7229	HNSC	TCGA	AGTSS	DEG_SPOP_SBC_1	556:560	Mutation rewiring degron network	0.1667
p.E566Q	DO15479	HNSC	ICGC	AGTSS	DEG_SPOP_SBC_1	556:560	Mutation rewiring degron network	0.1667
p.S564L	DO222817	BTCA	ICGC	AGTSS	DEG_SPOP_SBC_1	556:560	Mutation rewiring degron network	0.2222
p.E218V	DO222969	BTCA	ICGC	MTPYLD	LIG_APCC_ABBA_1	209:214	Mutation rewiring degron network	0.2222
p.T213I	DO222699	MELA	ICGC	MTPYLD	LIG_APCC_ABBA_1	209:214	Mutation altering degron motif	0.7078
p.Q548R	DO35242	PACA	ICGC	AGTSS	DEG_SPOP_SBC_1	556:560	Mutation rewiring degron network	0.1111
p.L563R	SIDM00370	T-Lymphoblastic Leukemia	GDSC	AGTSS	DEG_SPOP_SBC_1	556:560	Mutation rewiring degron network	0.25
p.L563R	ACH-000197	Leukemia	CCLE	AGTSS	DEG_SPOP_SBC_1	556:560	Mutation rewiring degron network	0.25
p.A547S	SIDM01129	Small Cell Lung Carcinoma	GDSC	AGTSS	DEG_SPOP_SBC_1	556:560	Mutation rewiring degron network	0.0833
p.A547S	ACH-000816	Lung Cancer	CCLE	AGTSS	DEG_SPOP_SBC_1	556:560	Mutation rewiring degron network	0.0833
p.A547S	NCI-H524	lung	COSMIC	AGTSS	DEG_SPOP_SBC_1	556:560	Mutation rewiring degron network	0.0833
p.A547T	SIDM00596	Endometrial Carcinoma	GDSC	AGTSS	DEG_SPOP_SBC_1	556:560	Mutation rewiring degron network	0.0833
p.A547T	SIDM01133	Other Solid Cancers	GDSC	AGTSS	DEG_SPOP_SBC_1	556:560	Mutation rewiring degron network	0.0833
p.A547T	ACH-001517	Endometrial/Uterine Cancer	CCLE	AGTSS	DEG_SPOP_SBC_1	556:560	Mutation rewiring degron network	0.0833
p.A547T	ACH-002177	Lung Cancer	CCLE	AGTSS	DEG_SPOP_SBC_1	556:560	Mutation rewiring degron network	0.0833
p.A547T	NCI-H835	lung	COSMIC	AGTSS	DEG_SPOP_SBC_1	556:560	Mutation rewiring degron network	0.0833
p.A547T	HEC-1	endometrium	COSMIC	AGTSS	DEG_SPOP_SBC_1	556:560	Mutation rewiring degron network	0.0833
p.P562L	SIDM01709	Melanoma	GDSC	AGTSS	DEG_SPOP_SBC_1	556:560	Mutation rewiring degron network	0.2778
p.P562L	ACH-000275	Non-Cancerous	CCLE	AGTSS	DEG_SPOP_SBC_1	556:560	Mutation rewiring degron network	0.2778
p.P211S	KS-1	central nervous system	COSMIC	MTPYLD	LIG_APCC_ABBA_1	209:214	Mutation altering degron motif	0.6752
p.E565K	SNU-81	large intestine	COSMIC	AGTSS	DEG_SPOP_SBC_1	556:560	Mutation rewiring degron network	0.1944
p.T550M	SNU-175	large intestine	COSMIC	AGTSS	DEG_SPOP_SBC_1	556:560	Mutation rewiring degron network	0.1667
p.T560M	SNU-175	large intestine	COSMIC	AGTSS	DEG_SPOP_SBC_1	556:560	Mutation altering degron motif	0.7423

Kaplan plot for NUB1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NUB1

UniProt ID: Q9Y5A7

Entrez ID: 51667

Protein name: NEDD8 ultimate buster 1 (Negative regulator of ubiquitin-like proteins 1) (Renal carcinoma antigen NY-REN-18)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NUB1 in