DegronMD

Uniprot ID: Q9Y5A7

Source protein: NEDD8 ultimate buster 1

Source gene: NUB1

Class: LIG_APCC_ABBA_1

Location: 209:214

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9693

ASA_SCORE: 55.7833

COIL: 0.6098

CONS_SCORE: 0.5213

DSS_SCORE: 0.3894

HELIX: 0.1752

FCONS_SCORE: 1.041

RIG_SCORE: 0.825

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E218V	DO222969	BTCA	ICGC	MTPYLD	LIG_APCC_ABBA_1	0.2222
p.T213I	DO222699	MELA	ICGC	MTPYLD	LIG_APCC_ABBA_1	0.7078
p.P211S	KS-1	central_nervous_system	COSMIC	MTPYLD	LIG_APCC_ABBA_1	0.6752

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y5A7	NEDD8 ultimate buster 1	LIG_APCC_ABBA_1	209:214	MTPYLD	APC,CDC20,FZR1	0.9693	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons