DegronMD - Q9P212(PLCE1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S1182N	TCGA-3B-A9HY	SARC	TCGA	VLSSS	DEG_SPOP_SBC_1	1175:1179	Mutation rewiring degron network	0.25
p.S1182N	TCGA-3B-A9HY	SARC	TCGA	AWSSS	DEG_SPOP_SBC_1	1186:1190	Mutation rewiring degron network	0.2222
p.S1182N	DO219938	SARC	ICGC	VLSSS	DEG_SPOP_SBC_1	1175:1179	Mutation rewiring degron network	0.25
p.S1182N	DO219938	SARC	ICGC	AWSSS	DEG_SPOP_SBC_1	1186:1190	Mutation rewiring degron network	0.2222
p.E1114D	TCGA-A8-A08G	BRCA	TCGA	KAKMHKE	LIG_APCC_ABBAyCdc20_2	1108:1114	Mutation altering degron motif	0.5647
p.A1162V	TCGA-AZ-6598	COAD	TCGA	AGTSS	DEG_SPOP_SBC_1	1162:1166	Mutation altering degron motif	0.5825
p.A1162V	DO10276	COAD	ICGC	AGTSS	DEG_SPOP_SBC_1	1162:1166	Mutation altering degron motif	0.5825
p.D1102N	TCGA-BR-6566	STAD	TCGA	KAKMHKE	LIG_APCC_ABBAyCdc20_2	1108:1114	Mutation rewiring degron network	0.1667
p.D1102N	DO38217	STAD	ICGC	KAKMHKE	LIG_APCC_ABBAyCdc20_2	1108:1114	Mutation rewiring degron network	0.1667
p.W1187L	TCGA-D3-A3CC	SKCM	TCGA	AWSSS	DEG_SPOP_SBC_1	1186:1190	Mutation altering degron motif	0.5904
p.W1187L	DO38171	SKCM	ICGC	AWSSS	DEG_SPOP_SBC_1	1186:1190	Mutation altering degron motif	0.5904
p.P1158S	TCGA-D3-A8GC	SKCM	TCGA	AGTSS	DEG_SPOP_SBC_1	1162:1166	Mutation rewiring degron network	0.2222
p.P1158S	DO50281	SKCM	ICGC	AGTSS	DEG_SPOP_SBC_1	1162:1166	Mutation rewiring degron network	0.2222
p.A1161V	TCGA-EO-A22U	UCEC	TCGA	AGTSS	DEG_SPOP_SBC_1	1162:1166	Mutation rewiring degron network	0.3056
p.A1161V	DO43755	UCEC	ICGC	AGTSS	DEG_SPOP_SBC_1	1162:1166	Mutation rewiring degron network	0.3056
p.P1167L	TCGA-FS-A1ZB	SKCM	TCGA	AGTSS	DEG_SPOP_SBC_1	1162:1166	Mutation rewiring degron network	0.3056
p.P1167L	TCGA-FS-A1ZB	SKCM	TCGA	VLSSS	DEG_SPOP_SBC_1	1175:1179	Mutation rewiring degron network	0.1111
p.L1176R	TCGA-VQ-A8E3	STAD	TCGA	VLSSS	DEG_SPOP_SBC_1	1175:1179	Mutation altering degron motif	0.7316
p.L1176R	DO51759	STAD	ICGC	VLSSS	DEG_SPOP_SBC_1	1175:1179	Mutation altering degron motif	0.7316
p.M1200I	DO48448	BLCA	ICGC	AWSSS	DEG_SPOP_SBC_1	1186:1190	Mutation rewiring degron network	0.0556
p.H1112R	DO224865	BRCA	ICGC	KAKMHKE	LIG_APCC_ABBAyCdc20_2	1108:1114	Mutation altering degron motif	0.8244
p.L1108I	DO8103	COAD	ICGC	KAKMHKE	LIG_APCC_ABBAyCdc20_2	1108:1114	Mutation altering degron motif	0.7174
p.T1106I	DO233855	GACA	ICGC	KAKMHKE	LIG_APCC_ABBAyCdc20_2	1108:1114	Mutation rewiring degron network	0.2778
p.S1182P	DO13863	GBM	ICGC	VLSSS	DEG_SPOP_SBC_1	1175:1179	Mutation rewiring degron network	0.25
p.S1182P	DO13863	GBM	ICGC	AWSSS	DEG_SPOP_SBC_1	1186:1190	Mutation rewiring degron network	0.2222
p.S1182P	DO42312	UCEC	ICGC	VLSSS	DEG_SPOP_SBC_1	1175:1179	Mutation rewiring degron network	0.25
p.S1182P	DO42312	UCEC	ICGC	AWSSS	DEG_SPOP_SBC_1	1186:1190	Mutation rewiring degron network	0.2222
p.C1115F	DO229019	LICA	ICGC	KAKMHKE	LIG_APCC_ABBAyCdc20_2	1108:1114	Mutation rewiring degron network	0.3056
p.L1183F	DO229028	LICA	ICGC	VLSSS	DEG_SPOP_SBC_1	1175:1179	Mutation rewiring degron network	0.2222
p.L1183F	DO229028	LICA	ICGC	AWSSS	DEG_SPOP_SBC_1	1186:1190	Mutation rewiring degron network	0.25
p.V1099L	DO229022	LICA	ICGC	KAKMHKE	LIG_APCC_ABBAyCdc20_2	1108:1114	Mutation rewiring degron network	0.0833
p.G1199S	DO50782	LICA	ICGC	AWSSS	DEG_SPOP_SBC_1	1186:1190	Mutation rewiring degron network	0.0833
p.T1164M	DO232761	PBCA	ICGC	AGTSS	DEG_SPOP_SBC_1	1162:1166	Mutation altering degron motif	0.7423
p.L1121F	DO229459	SKCA	ICGC	KAKMHKE	LIG_APCC_ABBAyCdc20_2	1108:1114	Mutation rewiring degron network	0.1389
p.A1161T	DO229453	SKCA	ICGC	AGTSS	DEG_SPOP_SBC_1	1162:1166	Mutation rewiring degron network	0.3056
p.G1198V	DO47683	SKCM	ICGC	AWSSS	DEG_SPOP_SBC_1	1186:1190	Mutation rewiring degron network	0.1111
p.R1195Q	SIDM00664	Pancreatic Carcinoma	GDSC	AWSSS	DEG_SPOP_SBC_1	1186:1190	Mutation rewiring degron network	0.1944
p.R1195Q	ACH-000178	Pancreatic Cancer	CCLE	AWSSS	DEG_SPOP_SBC_1	1186:1190	Mutation rewiring degron network	0.1944
p.R1195Q	Hs766T	pancreas	COSMIC	AWSSS	DEG_SPOP_SBC_1	1186:1190	Mutation rewiring degron network	0.1944
p.G1120V	SIDM00984	Other Blood Cancers	GDSC	KAKMHKE	LIG_APCC_ABBAyCdc20_2	1108:1114	Mutation rewiring degron network	0.1667
p.G1120V	ACH-001452	Leukemia	CCLE	KAKMHKE	LIG_APCC_ABBAyCdc20_2	1108:1114	Mutation rewiring degron network	0.1667
p.G1120V	BONNA-12	haematopoietic and lymphoid tissue	COSMIC	KAKMHKE	LIG_APCC_ABBAyCdc20_2	1108:1114	Mutation rewiring degron network	0.1667
p.S1173F	SIDM00433	T-Lymphoblastic Leukemia	GDSC	AGTSS	DEG_SPOP_SBC_1	1162:1166	Mutation rewiring degron network	0.1389
p.S1173F	SIDM00433	T-Lymphoblastic Leukemia	GDSC	VLSSS	DEG_SPOP_SBC_1	1175:1179	Mutation rewiring degron network	0.2778
p.S1173F	MOLT-13	haematopoietic and lymphoid tissue	COSMIC	AGTSS	DEG_SPOP_SBC_1	1162:1166	Mutation rewiring degron network	0.1389
p.S1173F	MOLT-13	haematopoietic and lymphoid tissue	COSMIC	VLSSS	DEG_SPOP_SBC_1	1175:1179	Mutation rewiring degron network	0.2778
p.T1104M	TOV-21G	ovary	COSMIC	KAKMHKE	LIG_APCC_ABBAyCdc20_2	1108:1114	Mutation rewiring degron network	0.2222
p.R1187Q	COLO-783	skin	COSMIC	AWSSS	DEG_SPOP_SBC_1	1186:1190	Mutation altering degron motif	0.7329

Kaplan plot for PLCE1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PLCE1

UniProt ID: Q9P212

Entrez ID: 51196

Protein name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 (EC 3.1.4.11) (Pancreas-enriched phospholipase C) (Phosphoinositide phospholipase C-epsilon-1) (Phospholipase C-epsilon-1) (PLC-epsilon-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PLCE1 in