DegronMD

Uniprot ID: Q9P212

Source protein: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1

Source gene: PLCE1

Class: DEG_SPOP_SBC_1

Location: 1186:1190

E3 ligase: SPOP

DEGRON score: 0.8674

ASA_SCORE: 63.36

COIL: 0.7186

CONS_SCORE: 0.3692

DSS_SCORE: 0.4362

HELIX: 0.2054

FCONS_SCORE: 1.1396

RIG_SCORE: 0.6183

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1182N	TCGA-3B-A9HY	SARC	TCGA	AWSSS	DEG_SPOP_SBC_1	0.2222
p.S1182N	DO219938	SARC	ICGC	AWSSS	DEG_SPOP_SBC_1	0.2222
p.W1187L	TCGA-D3-A3CC	SKCM	TCGA	AWSSS	DEG_SPOP_SBC_1	0.5904
p.W1187L	DO38171	SKCM	ICGC	AWSSS	DEG_SPOP_SBC_1	0.5904
p.M1200I	DO48448	BLCA	ICGC	AWSSS	DEG_SPOP_SBC_1	0.0556
p.S1182P	DO13863	GBM	ICGC	AWSSS	DEG_SPOP_SBC_1	0.2222
p.S1182P	DO42312	UCEC	ICGC	AWSSS	DEG_SPOP_SBC_1	0.2222
p.L1183F	DO229028	LICA	ICGC	AWSSS	DEG_SPOP_SBC_1	0.25
p.G1199S	DO50782	LICA	ICGC	AWSSS	DEG_SPOP_SBC_1	0.0833
p.G1198V	DO47683	SKCM	ICGC	AWSSS	DEG_SPOP_SBC_1	0.1111
p.R1195Q	SIDM00664	Pancreatic Carcinoma	GDSC	AWSSS	DEG_SPOP_SBC_1	0.1944
p.R1195Q	ACH-000178	Pancreatic Cancer	CCLE	AWSSS	DEG_SPOP_SBC_1	0.1944
p.R1195Q	Hs766T	pancreas	COSMIC	AWSSS	DEG_SPOP_SBC_1	0.1944
p.R1187Q	COLO-783	skin	COSMIC	AWSSS	DEG_SPOP_SBC_1	0.7329

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60504	Vinexin	DEG_SPOP_SBC_1	321:325	AWSSS	SPOP	0.8929	More...
Q3V6T2	Girdin	DEG_SPOP_SBC_1	1634:1638	AWSSS	SPOP	0.9294	More...
Q6ZN44	Netrin receptor UNC5A	DEG_SPOP_SBC_1	128:132	AWSSS	SPOP	0.6965	More...
Q9P212	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	DEG_SPOP_SBC_1	1186:1190	AWSSS	SPOP	0.8674	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons