DegronMD

Uniprot ID: Q6ZN44

Source protein: Netrin receptor UNC5A

Source gene: UNC5A

Class: DEG_SPOP_SBC_1

Location: 128:132

E3 ligase: SPOP

DEGRON score: 0.6965

ASA_SCORE: 51.48

COIL: 0.4814

CONS_SCORE: 0.415

DSS_SCORE: 0.1031

HELIX: 0.0026

FCONS_SCORE: 0.8824

RIG_SCORE: 0.8168

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V127M	TCGA-86-8668	LUAD	TCGA	AWSSS	DEG_SPOP_SBC_1	0.3056
p.V127M	DO228583	GACA	ICGC	AWSSS	DEG_SPOP_SBC_1	0.3056
p.V127M	DO25669	LUAD	ICGC	AWSSS	DEG_SPOP_SBC_1	0.3056
p.S132L	TCGA-B5-A11Y	UCEC	TCGA	AWSSS	DEG_SPOP_SBC_1	0.7667
p.S132L	DO40889	UCEC	ICGC	AWSSS	DEG_SPOP_SBC_1	0.7667
p.S132L	SIDM01451	Pancreatic Carcinoma	GDSC	AWSSS	DEG_SPOP_SBC_1	0.7667
p.S132L	ACH-000933	Pancreatic Cancer	CCLE	AWSSS	DEG_SPOP_SBC_1	0.7667
p.W129L	DO228974	LICA	ICGC	AWSSS	DEG_SPOP_SBC_1	0.5904
p.A140S	DO229038	LICA	ICGC	AWSSS	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60504	Vinexin	DEG_SPOP_SBC_1	321:325	AWSSS	SPOP	0.8929	More...
Q3V6T2	Girdin	DEG_SPOP_SBC_1	1634:1638	AWSSS	SPOP	0.9294	More...
Q6ZN44	Netrin receptor UNC5A	DEG_SPOP_SBC_1	128:132	AWSSS	SPOP	0.6965	More...
Q9P212	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	DEG_SPOP_SBC_1	1186:1190	AWSSS	SPOP	0.8674	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons