DegronMD

Uniprot ID: Q3V6T2

Source protein: Girdin

Source gene: CCDC88A

Class: DEG_SPOP_SBC_1

Location: 1634:1638

E3 ligase: SPOP

DEGRON score: 0.9294

ASA_SCORE: 82.24

COIL: 0.8318

CONS_SCORE: 0.657

DSS_SCORE: 0.4394

HELIX: 0.136

FCONS_SCORE: 1.0385

RIG_SCORE: 0.6082

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q1643K	TCGA-28-1750	GBM	TCGA	AWSSS	DEG_SPOP_SBC_1	0.1944
p.Q1643K	DO10930	GBM	ICGC	AWSSS	DEG_SPOP_SBC_1	0.1944
p.Q1643R	TCGA-5M-AAT6	COAD	TCGA	AWSSS	DEG_SPOP_SBC_1	0.1944
p.Q1643R	DO223703	COAD	ICGC	AWSSS	DEG_SPOP_SBC_1	0.1944
p.H1631N	TCGA-78-7535	LUAD	TCGA	AWSSS	DEG_SPOP_SBC_1	0.25
p.H1631N	DO24860	LUAD	ICGC	AWSSS	DEG_SPOP_SBC_1	0.25
p.E1632D	TCGA-DU-6392	LGG	TCGA	AWSSS	DEG_SPOP_SBC_1	0.2778
p.E1632D	DO22237	LGG	ICGC	AWSSS	DEG_SPOP_SBC_1	0.2778
p.D1630G	TCGA-E6-A1LX	UCEC	TCGA	AWSSS	DEG_SPOP_SBC_1	0.2222
p.D1630G	DO41020	UCEC	ICGC	AWSSS	DEG_SPOP_SBC_1	0.2222
p.S1626G	TCGA-HE-7128	KIRP	TCGA	AWSSS	DEG_SPOP_SBC_1	0.1111
p.S1626G	DO20796	KIRP	ICGC	AWSSS	DEG_SPOP_SBC_1	0.1111
p.S1635Y	DO228974	LICA	ICGC	AWSSS	DEG_SPOP_SBC_1	0.712
p.D1630E	DO229018	LICA	ICGC	AWSSS	DEG_SPOP_SBC_1	0.2222
p.S1626R	DO229009	LICA	ICGC	AWSSS	DEG_SPOP_SBC_1	0.1111
p.S1640T	SIDM00615	Hepatocellular Carcinoma	GDSC	AWSSS	DEG_SPOP_SBC_1	0.2778
p.S1640T	JHH-6	liver	COSMIC	AWSSS	DEG_SPOP_SBC_1	0.2778
p.T1635I	ACH-000764	Gastric Cancer	CCLE	AWSSS	DEG_SPOP_SBC_1	0.7078
p.S1641T	JHH-6	liver	COSMIC	AWSSS	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60504	Vinexin	DEG_SPOP_SBC_1	321:325	AWSSS	SPOP	0.8929	More...
Q3V6T2	Girdin	DEG_SPOP_SBC_1	1634:1638	AWSSS	SPOP	0.9294	More...
Q6ZN44	Netrin receptor UNC5A	DEG_SPOP_SBC_1	128:132	AWSSS	SPOP	0.6965	More...
Q9P212	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	DEG_SPOP_SBC_1	1186:1190	AWSSS	SPOP	0.8674	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons