DegronMD

Uniprot ID: Q9P212

Source protein: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1

Source gene: PLCE1

Class: LIG_APCC_ABBAyCdc20_2

Location: 1108:1114

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5444

ASA_SCORE: 103.9571

COIL: 0.3189

CONS_SCORE: 0.3473

DSS_SCORE: 0.6292

HELIX: 0.6591

FCONS_SCORE: 0.9354

RIG_SCORE: 0.7042

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1114D	TCGA-A8-A08G	BRCA	TCGA	KAKMHKE	LIG_APCC_ABBAyCdc20_2	0.5647
p.D1102N	TCGA-BR-6566	STAD	TCGA	KAKMHKE	LIG_APCC_ABBAyCdc20_2	0.1667
p.D1102N	DO38217	STAD	ICGC	KAKMHKE	LIG_APCC_ABBAyCdc20_2	0.1667
p.H1112R	DO224865	BRCA	ICGC	KAKMHKE	LIG_APCC_ABBAyCdc20_2	0.8244
p.L1108I	DO8103	COAD	ICGC	KAKMHKE	LIG_APCC_ABBAyCdc20_2	0.7174
p.T1106I	DO233855	GACA	ICGC	KAKMHKE	LIG_APCC_ABBAyCdc20_2	0.2778
p.C1115F	DO229019	LICA	ICGC	KAKMHKE	LIG_APCC_ABBAyCdc20_2	0.3056
p.V1099L	DO229022	LICA	ICGC	KAKMHKE	LIG_APCC_ABBAyCdc20_2	0.0833
p.L1121F	DO229459	SKCA	ICGC	KAKMHKE	LIG_APCC_ABBAyCdc20_2	0.1389
p.G1120V	SIDM00984	Other Blood Cancers	GDSC	KAKMHKE	LIG_APCC_ABBAyCdc20_2	0.1667
p.G1120V	ACH-001452	Leukemia	CCLE	KAKMHKE	LIG_APCC_ABBAyCdc20_2	0.1667
p.G1120V	BONNA-12	haematopoietic_and_lymphoid_tissue	COSMIC	KAKMHKE	LIG_APCC_ABBAyCdc20_2	0.1667
p.T1104M	TOV-21G	ovary	COSMIC	KAKMHKE	LIG_APCC_ABBAyCdc20_2	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P212	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	LIG_APCC_ABBAyCdc20_2	1108:1114	KAKMHKE	APC,CDC20,FZR1	0.5444	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons