DegronMD

Uniprot ID: P82094

Source protein: TATA element modulatory factor

Source gene: TMF1

Class: DEG_APCC_DBOX_1

Location: 768:776

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8811

ASA_SCORE: 98.3889

COIL: 0.116

CONS_SCORE: 0.7175

DSS_SCORE: 0.4608

HELIX: 0.8776

FCONS_SCORE: 1.4397

RIG_SCORE: 0.7675

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T768I	TCGA-96-A4JK	LUSC	TCGA	TRPLLRQIE	DEG_APCC_DBOX_1	0.5966
p.T768I	DO45442	LUSC	ICGC	TRPLLRQIE	DEG_APCC_DBOX_1	0.5966
p.Q779H	TCGA-A5-A0G1	UCEC	TCGA	TRPLLRQIE	DEG_APCC_DBOX_1	0.25
p.Q779H	DO42472	UCEC	ICGC	TRPLLRQIE	DEG_APCC_DBOX_1	0.25
p.S761G	TCGA-E6-A1LX	UCEC	TCGA	TRPLLRQIE	DEG_APCC_DBOX_1	0.1389
p.S761G	DO41020	UCEC	ICGC	TRPLLRQIE	DEG_APCC_DBOX_1	0.1389
p.Q782K	DO230343	COCA	ICGC	TRPLLRQIE	DEG_APCC_DBOX_1	0.1667
p.R759Q	DO230659	LAML	ICGC	TRPLLRQIE	DEG_APCC_DBOX_1	0.0833
p.R759Q	DO231140	LAML	ICGC	TRPLLRQIE	DEG_APCC_DBOX_1	0.0833
p.R759Q	SIDM00297	Non-Small Cell Lung Carcinoma	GDSC	TRPLLRQIE	DEG_APCC_DBOX_1	0.0833
p.R759Q	SIDM00606	Squamous Cell Lung Carcinoma	GDSC	TRPLLRQIE	DEG_APCC_DBOX_1	0.0833
p.R759Q	SIDM01551	Gastric Carcinoma	GDSC	TRPLLRQIE	DEG_APCC_DBOX_1	0.0833
p.R759Q	SIDM01451	Pancreatic Carcinoma	GDSC	TRPLLRQIE	DEG_APCC_DBOX_1	0.0833
p.L765I	CW-2	large_intestine	COSMIC	TRPLLRQIE	DEG_APCC_DBOX_1	0.25
p.E768G	EN	endometrium	COSMIC	TRPLLRQIE	DEG_APCC_DBOX_1	0.7199

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P82094	TATA element modulatory factor	DEG_APCC_DBOX_1	768:776	TRPLLRQIE	APC,CDC20,FZR1	0.8811	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons