DegronMD

Uniprot ID: P82094

Source protein: TATA element modulatory factor

Source gene: TMF1

Class: DEG_SCF_FBW7_1

Location: 926:933

E3 ligase: FBXW7

DEGRON score: 0.9984

ASA_SCORE: 98

COIL: 0.9403

CONS_SCORE: 0.2995

DSS_SCORE: 0.5646

HELIX: 0.0424

FCONS_SCORE: 1.0259

RIG_SCORE: 0.6427

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K922R	TCGA-06-2559	GBM	TCGA	VSSTPTMS	DEG_SCF_FBW7_1	0.3333
p.K922R	DO12610	GBM	ICGC	VSSTPTMS	DEG_SCF_FBW7_1	0.3333
p.S925Y	TCGA-39-5031	LUSC	TCGA	VSSTPTMS	DEG_SCF_FBW7_1	0.75
p.S925Y	DO26526	LUSC	ICGC	VSSTPTMS	DEG_SCF_FBW7_1	0.75
p.V941I	TCGA-D7-6527	STAD	TCGA	VSSTPTMS	DEG_SCF_FBW7_1	0.1111
p.V941I	DO38635	STAD	ICGC	VSSTPTMS	DEG_SCF_FBW7_1	0.1111
p.R934H	TCGA-DU-6392	LGG	TCGA	VSSTPTMS	DEG_SCF_FBW7_1	0.3056
p.R934H	DO230346	COCA	ICGC	VSSTPTMS	DEG_SCF_FBW7_1	0.3056
p.R934H	DO22237	LGG	ICGC	VSSTPTMS	DEG_SCF_FBW7_1	0.3056
p.R934H	DO232761	PBCA	ICGC	VSSTPTMS	DEG_SCF_FBW7_1	0.3056
p.R934C	TCGA-ZX-AA5X	CESC	TCGA	VSSTPTMS	DEG_SCF_FBW7_1	0.3056
p.R934C	DO219762	CESC	ICGC	VSSTPTMS	DEG_SCF_FBW7_1	0.3056
p.R934C	DO230343	COCA	ICGC	VSSTPTMS	DEG_SCF_FBW7_1	0.3056
p.S927Y	DO228974	LICA	ICGC	VSSTPTMS	DEG_SCF_FBW7_1	0.712
p.S930C	SIDM00473	Oral Cavity Carcinoma	GDSC	VSSTPTMS	DEG_SCF_FBW7_1	0.7541
p.S930C	PE/CA-PJ15	upper_aerodigestive_tract	COSMIC	VSSTPTMS	DEG_SCF_FBW7_1	0.7541
p.K922N	SIDM00215	Colorectal Carcinoma	GDSC	VSSTPTMS	DEG_SCF_FBW7_1	0.3333
p.K922N	SNU-283	large_intestine	COSMIC	VSSTPTMS	DEG_SCF_FBW7_1	0.3333
p.S936P	SIDM00220	Ovarian Carcinoma	GDSC	VSSTPTMS	DEG_SCF_FBW7_1	0.25
p.S936P	OC-314	ovary	COSMIC	VSSTPTMS	DEG_SCF_FBW7_1	0.25
p.R924H	SIDM01086	B-Lymphoblastic Leukemia	GDSC	VSSTPTMS	DEG_SCF_FBW7_1	0.2778
p.R924H	RS4-11	haematopoietic_and_lymphoid_tissue	COSMIC	VSSTPTMS	DEG_SCF_FBW7_1	0.2778
p.S927C	ACH-000619	Head and Neck Cancer	CCLE	VSSTPTMS	DEG_SCF_FBW7_1	0.7541
p.S927C	PE/CA-PJ15	upper_aerodigestive_tract	COSMIC	VSSTPTMS	DEG_SCF_FBW7_1	0.7541
p.R921H	ACH-000874	Leukemia	CCLE	VSSTPTMS	DEG_SCF_FBW7_1	0.1944
p.R921H	RS4-11	haematopoietic_and_lymphoid_tissue	COSMIC	VSSTPTMS	DEG_SCF_FBW7_1	0.1944
p.S933P	ACH-000962	Ovarian Cancer	CCLE	VSSTPTMS	DEG_SCF_FBW7_1	0.7863
p.S933P	ACH-001145	Ovarian Cancer	CCLE	VSSTPTMS	DEG_SCF_FBW7_1	0.7863
p.S933P	OC-314	ovary	COSMIC	VSSTPTMS	DEG_SCF_FBW7_1	0.7863
p.K919N	SNU-283	large_intestine	COSMIC	VSSTPTMS	DEG_SCF_FBW7_1	0.25
p.E929K	KYSE-410	oesophagus	COSMIC	VSSTPTMS	DEG_SCF_FBW7_1	0.7022
p.E929K	DIFI	large_intestine	COSMIC	VSSTPTMS	DEG_SCF_FBW7_1	0.7022

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VSSTPTMS

Degron related mutations and impact score

Drug responses associated with TMF1 mutations

All proteins holding degron of VSSTPTMS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P82094	TATA element modulatory factor	DEG_SCF_FBW7_1	926:933	VSSTPTMS	FBXW7	0.9984	More...