DegronMD

Uniprot ID: P82094

Source protein: TATA element modulatory factor

Source gene: TMF1

Class: DEG_SCF_FBW7_2

Location: 412:419

E3 ligase: FBXW7

DEGRON score: 0.9123

ASA_SCORE: 97.0875

COIL: 0.8998

CONS_SCORE: 0.3064

DSS_SCORE: 0.56

HELIX: 0.0709

FCONS_SCORE: 1.0039

RIG_SCORE: 0.6967

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N418D	TCGA-AP-A059	UCEC	TCGA	VSSTPINE	DEG_SCF_FBW7_2	0.5821
p.N418D	DO41361	UCEC	ICGC	VSSTPINE	DEG_SCF_FBW7_2	0.5821
p.E419K	TCGA-C5-A8XJ	CESC	TCGA	VSSTPINE	DEG_SCF_FBW7_2	0.7022
p.E419K	DO49902	CESC	ICGC	VSSTPINE	DEG_SCF_FBW7_2	0.7022
p.P408T	DO229035	LICA	ICGC	VSSTPINE	DEG_SCF_FBW7_2	0.2222
p.V403A	DO232761	PBCA	ICGC	VSSTPINE	DEG_SCF_FBW7_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P82094	TATA element modulatory factor	DEG_SCF_FBW7_2	412:419	VSSTPINE	FBXW7	0.9123	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons