DegronMD

Uniprot ID: Q6IQ55

Source protein: Tau-tubulin kinase 2

Source gene: TTBK2

Class: DEG_SCF_FBW7_1

Location: 1137:1143

E3 ligase: FBXW7

DEGRON score: 0.9686

ASA_SCORE: 106.4

COIL: 0.9594

CONS_SCORE: 0.3952

DSS_SCORE: 0.852

HELIX: 0.0146

FCONS_SCORE: 0.8763

RIG_SCORE: 0.505

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1130R	TCGA-DD-AADK	LIHC	TCGA	PKTPPKS	DEG_SCF_FBW7_1	0.1389
p.S1130R	DO52235	LIHC	ICGC	PKTPPKS	DEG_SCF_FBW7_1	0.1389
p.P1137L	TCGA-EO-A3B0	UCEC	TCGA	PKTPPKS	DEG_SCF_FBW7_1	0.6471
p.P1137L	DO219773	UCEC	ICGC	PKTPPKS	DEG_SCF_FBW7_1	0.6471
p.P1131L	TCGA-GF-A6C9	SKCM	TCGA	PKTPPKS	DEG_SCF_FBW7_1	0.1667
p.P1131L	DO51254	SKCM	ICGC	PKTPPKS	DEG_SCF_FBW7_1	0.1667
p.P1151H	TCGA-VS-A9UB	CESC	TCGA	PKTPPKS	DEG_SCF_FBW7_1	0.1111
p.P1151H	DO219731	CESC	ICGC	PKTPPKS	DEG_SCF_FBW7_1	0.1111
p.T1139K	DO228952	LICA	ICGC	PKTPPKS	DEG_SCF_FBW7_1	0.8417
p.P1140S	SIDM01483	Melanoma	GDSC	PKTPPKS	DEG_SCF_FBW7_1	0.6752
p.P1140S	ACH-000582	Skin Cancer	CCLE	PKTPPKS	DEG_SCF_FBW7_1	0.6752
p.P1140S	COLO-741	large_intestine	COSMIC	PKTPPKS	DEG_SCF_FBW7_1	0.6752
p.R1148H	SIDM01007	T-Lymphoblastic Leukemia	GDSC	PKTPPKS	DEG_SCF_FBW7_1	0.1944
p.R1148H	ACH-002256	Leukemia	CCLE	PKTPPKS	DEG_SCF_FBW7_1	0.1944
p.R1148H	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	PKTPPKS	DEG_SCF_FBW7_1	0.1944
p.S1152N	ACH-000961	Endometrial/Uterine Cancer	CCLE	PKTPPKS	DEG_SCF_FBW7_1	0.5278

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6IQ55	Tau-tubulin kinase 2	DEG_SCF_FBW7_1	1137:1143	PKTPPKS	FBXW7	0.9686	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons