DegronMD

Uniprot ID: Q6IQ55

Source protein: Tau-tubulin kinase 2

Source gene: TTBK2

Class: LIG_APCC_ABBA_1

Location: 859:864

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9665

ASA_SCORE: 80.3667

COIL: 0.7928

CONS_SCORE: 0.3424

DSS_SCORE: 0.565

HELIX: 0.163

FCONS_SCORE: 0.9393

RIG_SCORE: 0.7299

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D860G	TCGA-CK-4951	COAD	TCGA	IDPHVE	LIG_APCC_ABBA_1	0.6087
p.D860G	DO10582	COAD	ICGC	IDPHVE	LIG_APCC_ABBA_1	0.6087
p.S852L	TCGA-DK-A1A6	BLCA	TCGA	IDPHVE	LIG_APCC_ABBA_1	0.1389
p.S852L	DO472	BLCA	ICGC	IDPHVE	LIG_APCC_ABBA_1	0.1389
p.R857K	TCGA-DU-6407	LGG	TCGA	IDPHVE	LIG_APCC_ABBA_1	0.2778
p.R857K	DO22295	LGG	ICGC	IDPHVE	LIG_APCC_ABBA_1	0.2778
p.G850E	TCGA-FR-A3YO	SKCM	TCGA	IDPHVE	LIG_APCC_ABBA_1	0.0833
p.G850E	DO37419	SKCM	ICGC	IDPHVE	LIG_APCC_ABBA_1	0.0833
p.I854V	DO227993	COCA	ICGC	IDPHVE	LIG_APCC_ABBA_1	0.1944
p.E872D	SIDM00118	Colorectal Carcinoma	GDSC	IDPHVE	LIG_APCC_ABBA_1	0.1111
p.E872D	HCC2998	large_intestine	COSMIC	IDPHVE	LIG_APCC_ABBA_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6IQ55	Tau-tubulin kinase 2	LIG_APCC_ABBA_1	859:864	IDPHVE	APC,CDC20,FZR1	0.9665	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons