DegronMD

Uniprot ID: Q9H2D6

Source protein: TRIO and F-actin-binding protein

Source gene: TRIOBP

Class: DEG_APCC_KENBOX_2

Location: 1901:1905

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9732

ASA_SCORE: 93.58

COIL: 0.5068

CONS_SCORE: 0.7067

DSS_SCORE: 0.583

HELIX: 0.4718

FCONS_SCORE: 1.0553

RIG_SCORE: 0.6479

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D1893G	TCGA-D1-A17Q	UCEC	TCGA	NKENA	DEG_APCC_KENBOX_2	0.1111
p.D1893G	DO41903	UCEC	ICGC	NKENA	DEG_APCC_KENBOX_2	0.1111
p.A1891V	TCGA-DF-A2KU	UCEC	TCGA	NKENA	DEG_APCC_KENBOX_2	0.0556
p.A1891V	DO223286	UCEC	ICGC	NKENA	DEG_APCC_KENBOX_2	0.0556
p.A1905T	DO233882	GACA	ICGC	NKENA	DEG_APCC_KENBOX_2	0.6028
p.D1899Y	DO229045	LICA	ICGC	NKENA	DEG_APCC_KENBOX_2	0.2778
p.A1905S	DO50856	LICA	ICGC	NKENA	DEG_APCC_KENBOX_2	0.6477
p.Y1909C	DO222843	MELA	ICGC	NKENA	DEG_APCC_KENBOX_2	0.2222
p.K1902T	SIDM01184	Bladder Carcinoma	GDSC	NKENA	DEG_APCC_KENBOX_2	0.7306
p.K1902T	SIDM00964	Non-Cancerous	GDSC	NKENA	DEG_APCC_KENBOX_2	0.7306
p.E1903D	ACH-001416	Bladder Cancer	CCLE	NKENA	DEG_APCC_KENBOX_2	0.6758

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H2D6	TRIO and F-actin-binding protein	DEG_APCC_KENBOX_2	1901:1905	NKENA	APC,CDC20,FZR1	0.9732	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons