DegronMD

Uniprot ID: Q9H2D6

Source protein: TRIO and F-actin-binding protein

Source gene: TRIOBP

Class: DEG_APCC_DBOX_1

Location: 1939:1947

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9408

ASA_SCORE: 78.7556

COIL: 0.5569

CONS_SCORE: 0.6894

DSS_SCORE: 0.6231

HELIX: 0.2714

FCONS_SCORE: 1.0057

RIG_SCORE: 0.7414

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1930Q	TCGA-2L-AAQA	PAAD	TCGA	QRQALDYVE	DEG_APCC_DBOX_1	0.0833
p.R1930Q	DO51674	PAAD	ICGC	QRQALDYVE	DEG_APCC_DBOX_1	0.0833
p.P1933H	TCGA-AA-3947	COAD	TCGA	QRQALDYVE	DEG_APCC_DBOX_1	0.1667
p.P1933H	DO8192	COAD	ICGC	QRQALDYVE	DEG_APCC_DBOX_1	0.1667
p.R1930W	TCGA-AJ-A3EL	UCEC	TCGA	QRQALDYVE	DEG_APCC_DBOX_1	0.0833
p.R1930W	DO41542	UCEC	ICGC	QRQALDYVE	DEG_APCC_DBOX_1	0.0833
p.R1930W	DO42673	UCEC	ICGC	QRQALDYVE	DEG_APCC_DBOX_1	0.0833
p.L1948V	DO50387	ESAD	ICGC	QRQALDYVE	DEG_APCC_DBOX_1	0.3056
p.R1934Q	DO50698	ORCA	ICGC	QRQALDYVE	DEG_APCC_DBOX_1	0.1944
p.G1932D	ACH-000971	Colon/Colorectal Cancer	CCLE	QRQALDYVE	DEG_APCC_DBOX_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H2D6	TRIO and F-actin-binding protein	DEG_APCC_DBOX_1	1939:1947	QRQALDYVE	APC,CDC20,FZR1	0.9408	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons