DegronMD

Uniprot ID: Q9H2D6

Source protein: TRIO and F-actin-binding protein

Source gene: TRIOBP

Class: DEG_COP1_1

Location: 1143:1151

E3 ligase: COP1

DEGRON score: 0.8026

ASA_SCORE: 97.6444

COIL: 0.9473

CONS_SCORE: 0.6739

DSS_SCORE: 0.511

HELIX: 0.0384

FCONS_SCORE: 1.0252

RIG_SCORE: 0.6582

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1153C	TCGA-09-2056	OV	TCGA	STESLVPSM	DEG_COP1_1	0.2778
p.S1153C	DO29228	OV	ICGC	STESLVPSM	DEG_COP1_1	0.2778
p.S1146N	TCGA-EA-A410	CESC	TCGA	STESLVPSM	DEG_COP1_1	0.5958
p.S1146N	DO49929	CESC	ICGC	STESLVPSM	DEG_COP1_1	0.5958
p.E1145K	TCGA-FW-A3R5	SKCM	TCGA	STESLVPSM	DEG_COP1_1	0.591
p.E1145K	DO37406	SKCM	ICGC	STESLVPSM	DEG_COP1_1	0.591
p.R1141M	DO224563	LUSC	ICGC	STESLVPSM	DEG_COP1_1	0.2778
p.S1146R	SIDM00600	Thyroid Gland Carcinoma	GDSC	STESLVPSM	DEG_COP1_1	0.6316
p.S1146R	ACH-001528	Thyroid Cancer	CCLE	STESLVPSM	DEG_COP1_1	0.6316
p.S1146R	IHH-4	thyroid	COSMIC	STESLVPSM	DEG_COP1_1	0.6316
p.P1158L	SIDM00063	Melanoma	GDSC	STESLVPSM	DEG_COP1_1	0.1389
p.P1140H	ACH-001719	Ovarian Cancer	CCLE	STESLVPSM	DEG_COP1_1	0.25
p.S1150F	ACH-001982	Metastasis	CCLE	STESLVPSM	DEG_COP1_1	0.7982

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H2D6	TRIO and F-actin-binding protein	DEG_COP1_1	1143:1151	STESLVPSM	COP1	0.8026	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons