DegronMD

Uniprot ID: Q13625

Source protein: Apoptosis-stimulating of p53 protein 2

Source gene: TP53BP2

Class: DEG_SIAH_1

Location: 577:585

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.999

ASA_SCORE: 79.1444

COIL: 0.8331

CONS_SCORE: 0.4534

DSS_SCORE: 0.745

HELIX: 0.1009

FCONS_SCORE: 1.0746

RIG_SCORE: 0.6261

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G577V	DO231997	ORCA	ICGC	PPAAAVRPF	DEG_SIAH_1	0.7532
p.G577S	DO232761	PBCA	ICGC	PPAAAVRPF	DEG_SIAH_1	0.6993
p.D571E	TCGA-AX-A3FV	UCEC	TCGA	PPAAAVRPF	DEG_SIAH_1	0.1667
p.D571E	DO219767	UCEC	ICGC	PPAAAVRPF	DEG_SIAH_1	0.1667
p.P593S	TCGA-OL-A66I	BRCA	TCGA	PPAAAVRPF	DEG_SIAH_1	0.1111
p.P593S	DO44258	BRCA	ICGC	PPAAAVRPF	DEG_SIAH_1	0.1111
p.S567L	TCGA-B5-A1MR	UCEC	TCGA	PPAAAVRPF	DEG_SIAH_1	0.0556
p.S567L	DO41758	UCEC	ICGC	PPAAAVRPF	DEG_SIAH_1	0.0556

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13625	Apoptosis-stimulating of p53 protein 2	DEG_SIAH_1	577:585	PPAAAVRPF	SIAH1,SIAH2,SIAH3	0.999	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons