DegronMD

Uniprot ID: Q5THJ4

Source protein: Intermembrane lipid transfer protein VPS13D

Source gene: VPS13D

Class: DEG_COP1_1

Location: 2068:2078

E3 ligase: COP1

DEGRON score: 0.9697

ASA_SCORE: 73.6818

COIL: 0.7174

CONS_SCORE: 0.2643

DSS_SCORE: 0.4667

HELIX: 0.1503

FCONS_SCORE: 0.9122

RIG_SCORE: 0.6919

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S2068F	DO220881	MELA	ICGC	SLQDKESVPSA	DEG_COP1_1	0.7982
p.S2079F	TCGA-21-5783	LUSC	TCGA	SLQDKESVPSA	DEG_COP1_1	0.75
p.S2079F	DO27437	LUSC	ICGC	SLQDKESVPSA	DEG_COP1_1	0.75
p.P2076S	TCGA-AA-3966	COAD	TCGA	SLQDKESVPSA	DEG_COP1_1	0.6752
p.P2076S	DO10068	COAD	ICGC	SLQDKESVPSA	DEG_COP1_1	0.6752
p.S2074Y	TCGA-A5-A1OF	UCEC	TCGA	SLQDKESVPSA	DEG_COP1_1	0.6009
p.S2074Y	DO42568	UCEC	ICGC	SLQDKESVPSA	DEG_COP1_1	0.6009
p.F2067C	SIDM00850	Gastric Carcinoma	GDSC	SLQDKESVPSA	DEG_COP1_1	0.3056
p.F2067C	ACH-000880	Gastric Cancer	CCLE	SLQDKESVPSA	DEG_COP1_1	0.3056
p.F2067C	AGS	stomach	COSMIC	SLQDKESVPSA	DEG_COP1_1	0.3056
p.G2065D	TCGA-AX-A3FT	UCEC	TCGA	SLQDKESVPSA	DEG_COP1_1	0.25
p.G2065D	DO40801	UCEC	ICGC	SLQDKESVPSA	DEG_COP1_1	0.25

Showing 1 to 12 of 12 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5THJ4	Intermembrane lipid transfer protein VPS13D	DEG_COP1_1	2068:2078	SLQDKESVPSA	COP1	0.9697	More...

Showing 1 to 1 of 1 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons