DegronMD

Uniprot ID: Q5THJ4

Source protein: Intermembrane lipid transfer protein VPS13D

Source gene: VPS13D

Class: DEG_SCF_FBW7_1

Location: 771:778

E3 ligase: FBXW7

DEGRON score: 0.9959

ASA_SCORE: 84.775

COIL: 0.944

CONS_SCORE: 0.3114

DSS_SCORE: 0.8393

HELIX: 0.0264

FCONS_SCORE: 1.1277

RIG_SCORE: 0.5599

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A773V	TCGA-B5-A3FA	UCEC	TCGA	PLATPPNT	DEG_SCF_FBW7_1	0.5825
p.A773V	DO52402	UCEC	ICGC	PLATPPNT	DEG_SCF_FBW7_1	0.5825
p.E767K	DO11854	GBM	ICGC	PLATPPNT	DEG_SCF_FBW7_1	0.2222
p.P771L	DO229459	SKCA	ICGC	PLATPPNT	DEG_SCF_FBW7_1	0.6471

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5THJ4	Intermembrane lipid transfer protein VPS13D	DEG_SCF_FBW7_1	771:778	PLATPPNT	FBXW7	0.9959	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons