DegronMD: protein-targeted degradation, mutation and drug response to degrons
Home
(current)
Browse
Proteins/Degrons
Mutations
Drug response
Network-rewiring
Drug resistance
Search
Tutorial
Download
Contact
Links
BSML
CPH
CGC
Degron:
PPNTPPPE
Uniprot ID:
Q5THJ4
Source protein:
Intermembrane lipid transfer protein VPS13D
Source gene:
VPS13D
Class:
DEG_SCF_FBW7_2
Location:
775:782
E3 ligase:
FBXW7
DEGRON score:
0.8801
ASA_SCORE:
95.75
COIL:
0.9565
CONS_SCORE:
0.2792
DSS_SCORE:
0.8576
HELIX:
0.0228
FCONS_SCORE:
0.9759
RIG_SCORE:
0.5147
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.E767K
DO11854
GBM
ICGC
PPNTPPPE
DEG_SCF_FBW7_2
0.1111
Drug responses associated with VPS13D mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PPNTPPPE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q5THJ4
Intermembrane lipid transfer protein VPS13D
DEG_SCF_FBW7_2
775:782
PPNTPPPE
FBXW7
0.8801
More...