DegronMD

Uniprot ID: Q5THJ4

Source protein: Intermembrane lipid transfer protein VPS13D

Source gene: VPS13D

Class: LIG_APCC_ABBA_1

Location: 203:208

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5954

ASA_SCORE: 15.9833

COIL: 0.1483

CONS_SCORE: 0.5664

DSS_SCORE: 0.0481

HELIX: 0.0047

FCONS_SCORE: 1.5009

RIG_SCORE: 0.9232

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A208V	DO8447	COAD	ICGC	FSIYWD	LIG_APCC_ABBA_1	0.6936
p.P218L	DO234173	ESAD	ICGC	FSIYWD	LIG_APCC_ABBA_1	0.0556
p.A202S	DO228952	LICA	ICGC	FSIYWD	LIG_APCC_ABBA_1	0.3056
p.R194L	DO229022	LICA	ICGC	FSIYWD	LIG_APCC_ABBA_1	0.0833
p.Q207H	DO229027	LICA	ICGC	FSIYWD	LIG_APCC_ABBA_1	0.7582
p.R210K	DO26508	LUSC	ICGC	FSIYWD	LIG_APCC_ABBA_1	0.2778
p.A198S	DO50726	ORCA	ICGC	FSIYWD	LIG_APCC_ABBA_1	0.1944
p.L199P	DO219881	SKCA	ICGC	FSIYWD	LIG_APCC_ABBA_1	0.2222
p.L215V	DO229456	SKCA	ICGC	FSIYWD	LIG_APCC_ABBA_1	0.1389
p.A213T	DO37782	SKCM	ICGC	FSIYWD	LIG_APCC_ABBA_1	0.1944
p.S216G	DO229253	THCA	ICGC	FSIYWD	LIG_APCC_ABBA_1	0.1111
p.G217C	DO229211	THCA	ICGC	FSIYWD	LIG_APCC_ABBA_1	0.0833
p.G217S	DO41331	UCEC	ICGC	FSIYWD	LIG_APCC_ABBA_1	0.0833
p.I205V	SIDM01023	Acute Myeloid Leukemia	GDSC	FSIYWD	LIG_APCC_ABBA_1	0.5965
p.I205V	SIDM00082	Melanoma	GDSC	FSIYWD	LIG_APCC_ABBA_1	0.5965
p.I205V	SIDM00482	Chronic Myelogenous Leukemia	GDSC	FSIYWD	LIG_APCC_ABBA_1	0.5965
p.I205V	SIDM00658	Non-Small Cell Lung Carcinoma	GDSC	FSIYWD	LIG_APCC_ABBA_1	0.5965
p.I205V	SIDM01775	B-Cell Non-Hodgkin's Lymphoma	GDSC	FSIYWD	LIG_APCC_ABBA_1	0.5965
p.G215R	SIDM00718	Non-Small Cell Lung Carcinoma	GDSC	FSIYWD	LIG_APCC_ABBA_1	0.1389
p.G215R	ACH-000860	Lung Cancer	CCLE	FSIYWD	LIG_APCC_ABBA_1	0.1389
p.G215R	NCI-H358	lung	COSMIC	FSIYWD	LIG_APCC_ABBA_1	0.1389
p.I205M	SIDM00937	Oral Cavity Carcinoma	GDSC	FSIYWD	LIG_APCC_ABBA_1	0.6507
p.I205M	CAL-27	upper_aerodigestive_tract	COSMIC	FSIYWD	LIG_APCC_ABBA_1	0.6507
p.D216N	ACH-000982	Colon/Colorectal Cancer	CCLE	FSIYWD	LIG_APCC_ABBA_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5THJ4	Intermembrane lipid transfer protein VPS13D	LIG_APCC_ABBA_1	203:208	FSIYWD	APC,CDC20,FZR1	0.5954	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons