DegronMD

Uniprot ID: Q5THJ4

Source protein: Intermembrane lipid transfer protein VPS13D

Source gene: VPS13D

Class: DEG_APCC_DBOX_1

Location: 3643:3651

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7871

ASA_SCORE: 59.2556

COIL: 0.479

CONS_SCORE: 0.2936

DSS_SCORE: 0.5833

HELIX: 0.0249

FCONS_SCORE: 1.0537

RIG_SCORE: 0.7444

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T3653A	TCGA-AP-A056	UCEC	TCGA	KRSQLWRMT	DEG_APCC_DBOX_1	0.2778
p.T3653A	TCGA-XJ-A9DX	PRAD	TCGA	KRSQLWRMT	DEG_APCC_DBOX_1	0.2778
p.T3653A	DO51402	PRAD	ICGC	KRSQLWRMT	DEG_APCC_DBOX_1	0.2778
p.T3653A	DO43971	UCEC	ICGC	KRSQLWRMT	DEG_APCC_DBOX_1	0.2778
p.R3644C	TCGA-CM-4744	COAD	TCGA	KRSQLWRMT	DEG_APCC_DBOX_1	0.8301
p.R3644C	DO8882	COAD	ICGC	KRSQLWRMT	DEG_APCC_DBOX_1	0.8301
p.M3650T	DO222454	BTCA	ICGC	KRSQLWRMT	DEG_APCC_DBOX_1	0.7423
p.R3649H	DO233206	GACA	ICGC	KRSQLWRMT	DEG_APCC_DBOX_1	0.7133
p.G3654V	DO229018	LICA	ICGC	KRSQLWRMT	DEG_APCC_DBOX_1	0.25
p.G3653V	DO229009	LICA	ICGC	KRSQLWRMT	DEG_APCC_DBOX_1	0.2778
p.A3648V	DO23846	LUAD	ICGC	KRSQLWRMT	DEG_APCC_DBOX_1	0.6936
p.E3652K	DO222521	MELA	ICGC	KRSQLWRMT	DEG_APCC_DBOX_1	0.3056
p.P3642L	DO219501	SKCM	ICGC	KRSQLWRMT	DEG_APCC_DBOX_1	0.3056
p.T3653I	SIDM00683	Prostate Carcinoma	GDSC	KRSQLWRMT	DEG_APCC_DBOX_1	0.2778
p.T3653I	ACH-000977	lymph_node	CCLE	KRSQLWRMT	DEG_APCC_DBOX_1	0.2778
p.T3653I	LNCaP-Clone-FGC	prostate	COSMIC	KRSQLWRMT	DEG_APCC_DBOX_1	0.2778
p.G3652E	SIDM00545	Melanoma	GDSC	KRSQLWRMT	DEG_APCC_DBOX_1	0.3056
p.G3652E	ACH-000987	Skin Cancer	CCLE	KRSQLWRMT	DEG_APCC_DBOX_1	0.3056
p.G3652E	Mewo	skin	COSMIC	KRSQLWRMT	DEG_APCC_DBOX_1	0.3056
p.H3658Y	SIDM00927	Small Cell Lung Carcinoma	GDSC	KRSQLWRMT	DEG_APCC_DBOX_1	0.1389
p.H3658Y	ACH-000871	Lung Cancer	CCLE	KRSQLWRMT	DEG_APCC_DBOX_1	0.1389
p.H3658Y	NCI-H510A	lung	COSMIC	KRSQLWRMT	DEG_APCC_DBOX_1	0.1389
p.H3633Y	NCI-H510A	lung	COSMIC	KRSQLWRMT	DEG_APCC_DBOX_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5THJ4	Intermembrane lipid transfer protein VPS13D	DEG_APCC_DBOX_1	3643:3651	KRSQLWRMT	APC,CDC20,FZR1	0.7871	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons