DegronMD

Uniprot ID: Q5THJ4

Source protein: Intermembrane lipid transfer protein VPS13D

Source gene: VPS13D

Class: DEG_APCC_KENBOX_2

Location: 3150:3154

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6929

ASA_SCORE: 81.28

COIL: 0.642

CONS_SCORE: 0.3862

DSS_SCORE: 0.1199

HELIX: 0.037

FCONS_SCORE: 1.3075

RIG_SCORE: 0.8042

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.C3146F	TCGA-60-2710	LUSC	TCGA	KKENY	DEG_APCC_KENBOX_2	0.2222
p.C3146F	TCGA-98-A538	LUSC	TCGA	KKENY	DEG_APCC_KENBOX_2	0.2222
p.N3161S	TCGA-76-6283	GBM	TCGA	KKENY	DEG_APCC_KENBOX_2	0.1389
p.N3161S	DO223727	GBM	ICGC	KKENY	DEG_APCC_KENBOX_2	0.1389
p.E3152D	TCGA-BK-A6W3	UCEC	TCGA	KKENY	DEG_APCC_KENBOX_2	0.6758
p.E3152D	TCGA-D1-A17Q	UCEC	TCGA	KKENY	DEG_APCC_KENBOX_2	0.6758
p.E3152D	TCGA-EY-A1G8	UCEC	TCGA	KKENY	DEG_APCC_KENBOX_2	0.6758
p.E3152D	DO50076	UCEC	ICGC	KKENY	DEG_APCC_KENBOX_2	0.6758
p.E3152D	DO43578	UCEC	ICGC	KKENY	DEG_APCC_KENBOX_2	0.6758
p.E3152D	DO41903	UCEC	ICGC	KKENY	DEG_APCC_KENBOX_2	0.6758
p.P3159H	SIDM01090	Colorectal Carcinoma	GDSC	KKENY	DEG_APCC_KENBOX_2	0.1944
p.P3159H	ACH-000943	Colon/Colorectal Cancer	CCLE	KKENY	DEG_APCC_KENBOX_2	0.1944
p.P3159H	RKO	large_intestine	COSMIC	KKENY	DEG_APCC_KENBOX_2	0.1944
p.Q3148H	HCT-15	large_intestine	COSMIC	KKENY	DEG_APCC_KENBOX_2	0.2778
p.L3164S	SNU-1040	large_intestine	COSMIC	KKENY	DEG_APCC_KENBOX_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15858	Sodium channel protein type 9 subunit alpha	DEG_APCC_KENBOX_2	1033:1037	KKENY	APC,CDC20,FZR1	0.7261	More...
Q5THJ4	Intermembrane lipid transfer protein VPS13D	DEG_APCC_KENBOX_2	3150:3154	KKENY	APC,CDC20,FZR1	0.6929	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons