DegronMD

Uniprot ID: Q15858

Source protein: Sodium channel protein type 9 subunit alpha

Source gene: SCN9A

Class: DEG_APCC_KENBOX_2

Location: 1033:1037

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7261

ASA_SCORE: 97.54

COIL: 0.6756

CONS_SCORE: 0.2812

DSS_SCORE: 0.4058

HELIX: 0.2466

FCONS_SCORE: 1.0301

RIG_SCORE: 0.7413

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1031A	TCGA-AZ-6601	COAD	TCGA	KKENY	DEG_APCC_KENBOX_2	0.2778
p.E1024K	TCGA-D3-A3C7	SKCM	TCGA	KKENY	DEG_APCC_KENBOX_2	0.0833
p.E1024K	TCGA-D3-A8GM	SKCM	TCGA	KKENY	DEG_APCC_KENBOX_2	0.0833
p.K1047E	TCGA-DX-AB2E	SARC	TCGA	KKENY	DEG_APCC_KENBOX_2	0.0556
p.T1042A	DO8119	COAD	ICGC	KKENY	DEG_APCC_KENBOX_2	0.1944
p.K1034T	DO234389	ESAD	ICGC	KKENY	DEG_APCC_KENBOX_2	0.7306
p.S1047R	DO233723	GACA	ICGC	KKENY	DEG_APCC_KENBOX_2	0.0556
p.N1031D	DO231033	LUSC	ICGC	KKENY	DEG_APCC_KENBOX_2	0.2778
p.E1035K	DO220912	MELA	ICGC	KKENY	DEG_APCC_KENBOX_2	0.7022
p.E1035K	DO50288	SKCM	ICGC	KKENY	DEG_APCC_KENBOX_2	0.7022
p.E1035K	DO47569	SKCM	ICGC	KKENY	DEG_APCC_KENBOX_2	0.7022
p.E1023K	DO37437	SKCM	ICGC	KKENY	DEG_APCC_KENBOX_2	0.0556
p.D1046E	SIDM00871	Non-Cancerous	GDSC	KKENY	DEG_APCC_KENBOX_2	0.0833
p.D1046E	SIDM00872	Breast Carcinoma	GDSC	KKENY	DEG_APCC_KENBOX_2	0.0833
p.D1046E	ACH-002384	Non-Cancerous	CCLE	KKENY	DEG_APCC_KENBOX_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15858	Sodium channel protein type 9 subunit alpha	DEG_APCC_KENBOX_2	1033:1037	KKENY	APC,CDC20,FZR1	0.7261	More...
Q5THJ4	Intermembrane lipid transfer protein VPS13D	DEG_APCC_KENBOX_2	3150:3154	KKENY	APC,CDC20,FZR1	0.6929	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons