DegronMD - P0C6C1(ANKRD34C)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E421D	TCGA-AJ-A3EL	UCEC	TCGA	SRESLDTVP	DEG_APCC_DBOX_1	419:427	Mutation altering degron motif	0.5647
p.E421D	DO41542	UCEC	ICGC	SRESLDTVP	DEG_APCC_DBOX_1	419:427	Mutation altering degron motif	0.5647
p.P427L	TCGA-BG-A222	UCEC	TCGA	SRESLDTVP	DEG_APCC_DBOX_1	419:427	Mutation altering degron motif	0.6471
p.P427L	TCGA-BG-A222	UCEC	TCGA	VPSTS	DEG_SPOP_SBC_1	426:430	Mutation altering degron motif	0.6471
p.P427L	TCGA-LN-A4MR	ESCA	TCGA	SRESLDTVP	DEG_APCC_DBOX_1	419:427	Mutation altering degron motif	0.6471
p.P427L	TCGA-LN-A4MR	ESCA	TCGA	VPSTS	DEG_SPOP_SBC_1	426:430	Mutation altering degron motif	0.6471
p.P427L	DO42977	UCEC	ICGC	SRESLDTVP	DEG_APCC_DBOX_1	419:427	Mutation altering degron motif	0.6471
p.P427L	DO42977	UCEC	ICGC	VPSTS	DEG_SPOP_SBC_1	426:430	Mutation altering degron motif	0.6471
p.R436H	TCGA-CM-6170	COAD	TCGA	SRESLDTVP	DEG_APCC_DBOX_1	419:427	Mutation rewiring degron network	0.0833
p.R436H	TCGA-CM-6170	COAD	TCGA	VPSTS	DEG_SPOP_SBC_1	426:430	Mutation rewiring degron network	0.1667
p.R436H	DO7849	COAD	ICGC	SRESLDTVP	DEG_APCC_DBOX_1	419:427	Mutation rewiring degron network	0.0833
p.R436H	DO7849	COAD	ICGC	VPSTS	DEG_SPOP_SBC_1	426:430	Mutation rewiring degron network	0.1667
p.R420W	DO229359	BTCA	ICGC	SRESLDTVP	DEG_APCC_DBOX_1	419:427	Mutation altering degron motif	0.8634
p.R420W	DO233636	GACA	ICGC	SRESLDTVP	DEG_APCC_DBOX_1	419:427	Mutation altering degron motif	0.8634
p.R420W	ACH-001443	Thyroid Cancer	CCLE	SRESLDTVP	DEG_APCC_DBOX_1	419:427	Mutation altering degron motif	0.8634
p.R436C	DO9732	COAD	ICGC	SRESLDTVP	DEG_APCC_DBOX_1	419:427	Mutation rewiring degron network	0.0833
p.R436C	DO9732	COAD	ICGC	VPSTS	DEG_SPOP_SBC_1	426:430	Mutation rewiring degron network	0.1667
p.S411F	DO222874	COCA	ICGC	SRESLDTVP	DEG_APCC_DBOX_1	419:427	Mutation rewiring degron network	0.1111
p.S414Y	DO233205	GACA	ICGC	SRESLDTVP	DEG_APCC_DBOX_1	419:427	Mutation rewiring degron network	0.1944
p.T233N	DO228667	LICA	ICGC	KRARLPQLK	DEG_APCC_DBOX_1	240:248	Mutation rewiring degron network	0.1389
p.R249S	DO228948	LICA	ICGC	KRARLPQLK	DEG_APCC_DBOX_1	240:248	Mutation rewiring degron network	0.3056
p.A242S	DO228974	LICA	ICGC	KRARLPQLK	DEG_APCC_DBOX_1	240:248	Mutation altering degron motif	0.6477
p.G418V	DO229025	LICA	ICGC	SRESLDTVP	DEG_APCC_DBOX_1	419:427	Mutation rewiring degron network	0.3056
p.G418V	DO229025	LICA	ICGC	VPSTS	DEG_SPOP_SBC_1	426:430	Mutation rewiring degron network	0.1111
p.R436L	DO229031	LICA	ICGC	SRESLDTVP	DEG_APCC_DBOX_1	419:427	Mutation rewiring degron network	0.0833
p.R436L	DO229031	LICA	ICGC	VPSTS	DEG_SPOP_SBC_1	426:430	Mutation rewiring degron network	0.1667
p.L239I	DO229052	LICA	ICGC	KRARLPQLK	DEG_APCC_DBOX_1	240:248	Mutation rewiring degron network	0.3056
p.H440Q	DO26469	LUSC	ICGC	VPSTS	DEG_SPOP_SBC_1	426:430	Mutation rewiring degron network	0.0556
p.E421K	DO229462	SKCA	ICGC	SRESLDTVP	DEG_APCC_DBOX_1	419:427	Mutation altering degron motif	0.591
p.S428G	SIDM01954	Colorectal Carcinoma	GDSC	VPSTS	DEG_SPOP_SBC_1	426:430	Mutation altering degron motif	0.6993
p.S252C	ACH-000910	Breast Cancer	CCLE	KRARLPQLK	DEG_APCC_DBOX_1	240:248	Mutation blocking phosphorylation signal	0.6667
p.S231P	ACH-000943	Colon/Colorectal Cancer	CCLE	KRARLPQLK	DEG_APCC_DBOX_1	240:248	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ANKRD34C

UniProt ID: P0C6C1

Entrez ID: 390616

Protein name: Ankyrin repeat domain-containing protein 34C

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ANKRD34C in