DegronMD

Uniprot ID: P0C6C1

Source protein: Ankyrin repeat domain-containing protein 34C

Source gene: ANKRD34C

Class: DEG_APCC_DBOX_1

Location: 240:248

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7731

ASA_SCORE: 81.2222

COIL: 0.4112

CONS_SCORE: 0.5551

DSS_SCORE: 0.5093

HELIX: 0.5683

FCONS_SCORE: 1.1604

RIG_SCORE: 0.7744

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T233N	DO228667	LICA	ICGC	KRARLPQLK	DEG_APCC_DBOX_1	0.1389
p.R249S	DO228948	LICA	ICGC	KRARLPQLK	DEG_APCC_DBOX_1	0.3056
p.A242S	DO228974	LICA	ICGC	KRARLPQLK	DEG_APCC_DBOX_1	0.6477
p.L239I	DO229052	LICA	ICGC	KRARLPQLK	DEG_APCC_DBOX_1	0.3056
p.S252C	ACH-000910	Breast Cancer	CCLE	KRARLPQLK	DEG_APCC_DBOX_1	0.6667
p.S231P	ACH-000943	Colon/Colorectal Cancer	CCLE	KRARLPQLK	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P0C6C1	Ankyrin repeat domain-containing protein 34C	DEG_APCC_DBOX_1	240:248	KRARLPQLK	APC,CDC20,FZR1	0.7731	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons