DegronMD

Uniprot ID: P0C6C1

Source protein: Ankyrin repeat domain-containing protein 34C

Source gene: ANKRD34C

Class: DEG_APCC_DBOX_1

Location: 419:427

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9788

ASA_SCORE: 77.1111

COIL: 0.8412

CONS_SCORE: 0.4023

DSS_SCORE: 0.6182

HELIX: 0.1137

FCONS_SCORE: 0.9357

RIG_SCORE: 0.607

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E421D	TCGA-AJ-A3EL	UCEC	TCGA	SRESLDTVP	DEG_APCC_DBOX_1	0.5647
p.E421D	DO41542	UCEC	ICGC	SRESLDTVP	DEG_APCC_DBOX_1	0.5647
p.P427L	TCGA-BG-A222	UCEC	TCGA	SRESLDTVP	DEG_APCC_DBOX_1	0.6471
p.P427L	TCGA-LN-A4MR	ESCA	TCGA	SRESLDTVP	DEG_APCC_DBOX_1	0.6471
p.P427L	DO42977	UCEC	ICGC	SRESLDTVP	DEG_APCC_DBOX_1	0.6471
p.R436H	TCGA-CM-6170	COAD	TCGA	SRESLDTVP	DEG_APCC_DBOX_1	0.0833
p.R436H	DO7849	COAD	ICGC	SRESLDTVP	DEG_APCC_DBOX_1	0.0833
p.R420W	DO229359	BTCA	ICGC	SRESLDTVP	DEG_APCC_DBOX_1	0.8634
p.R420W	DO233636	GACA	ICGC	SRESLDTVP	DEG_APCC_DBOX_1	0.8634
p.R420W	ACH-001443	Thyroid Cancer	CCLE	SRESLDTVP	DEG_APCC_DBOX_1	0.8634
p.R436C	DO9732	COAD	ICGC	SRESLDTVP	DEG_APCC_DBOX_1	0.0833
p.S411F	DO222874	COCA	ICGC	SRESLDTVP	DEG_APCC_DBOX_1	0.1111
p.S414Y	DO233205	GACA	ICGC	SRESLDTVP	DEG_APCC_DBOX_1	0.1944
p.G418V	DO229025	LICA	ICGC	SRESLDTVP	DEG_APCC_DBOX_1	0.3056
p.R436L	DO229031	LICA	ICGC	SRESLDTVP	DEG_APCC_DBOX_1	0.0833
p.E421K	DO229462	SKCA	ICGC	SRESLDTVP	DEG_APCC_DBOX_1	0.591

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P0C6C1	Ankyrin repeat domain-containing protein 34C	DEG_APCC_DBOX_1	419:427	SRESLDTVP	APC,CDC20,FZR1	0.9788	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons