DegronMD - Q96PU4(UHRF2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P77R	TCGA-A3-3362	KIRC	TCGA	PGTST	DEG_SPOP_SBC_1	81:85	Mutation rewiring degron network	0.2222
p.P77R	DO19683	KIRC	ICGC	PGTST	DEG_SPOP_SBC_1	81:85	Mutation rewiring degron network	0.2222
p.E184D	TCGA-AJ-A3EK	UCEC	TCGA	VPSTS	DEG_SPOP_SBC_1	192:196	Mutation rewiring degron network	0.1111
p.E184D	DO41584	UCEC	ICGC	VPSTS	DEG_SPOP_SBC_1	192:196	Mutation rewiring degron network	0.1111
p.S182F	TCGA-DK-AA6L	BLCA	TCGA	VPSTS	DEG_SPOP_SBC_1	192:196	Mutation rewiring degron network	0.0556
p.S182F	DO219002	BLCA	ICGC	VPSTS	DEG_SPOP_SBC_1	192:196	Mutation rewiring degron network	0.0556
p.S84C	TCGA-DR-A0ZM	CESC	TCGA	PGTST	DEG_SPOP_SBC_1	81:85	Mutation altering degron motif	0.7541
p.S84C	DO6254	CESC	ICGC	PGTST	DEG_SPOP_SBC_1	81:85	Mutation altering degron motif	0.7541
p.T195M	TCGA-DS-A0VK	CESC	TCGA	VPSTS	DEG_SPOP_SBC_1	192:196	Mutation altering degron motif	0.7423
p.T195M	DO6256	CESC	ICGC	VPSTS	DEG_SPOP_SBC_1	192:196	Mutation altering degron motif	0.7423
p.D199Y	TCGA-EE-A3AD	SKCM	TCGA	VPSTS	DEG_SPOP_SBC_1	192:196	Mutation rewiring degron network	0.25
p.D199Y	DO37707	SKCM	ICGC	VPSTS	DEG_SPOP_SBC_1	192:196	Mutation rewiring degron network	0.25
p.D78G	TCGA-MP-A4TJ	LUAD	TCGA	PGTST	DEG_SPOP_SBC_1	81:85	Mutation rewiring degron network	0.25
p.D78G	DO45394	LUAD	ICGC	PGTST	DEG_SPOP_SBC_1	81:85	Mutation rewiring degron network	0.25
p.G82D	DO222798	COCA	ICGC	PGTST	DEG_SPOP_SBC_1	81:85	Mutation altering degron motif	0.6087
p.P91S	DO228581	GACA	ICGC	PGTST	DEG_SPOP_SBC_1	81:85	Mutation rewiring degron network	0.1667
p.Q86H	DO229026	LICA	ICGC	PGTST	DEG_SPOP_SBC_1	81:85	Mutation rewiring degron network	0.3056
p.T195A	SIDM00421	T-Cell Non-Hodgkin's Lymphoma	GDSC	VPSTS	DEG_SPOP_SBC_1	192:196	Mutation altering degron motif	0.7139
p.T195A	SIDM01483	Melanoma	GDSC	VPSTS	DEG_SPOP_SBC_1	192:196	Mutation altering degron motif	0.7139
p.T195A	SIDM00188	Kidney Carcinoma	GDSC	VPSTS	DEG_SPOP_SBC_1	192:196	Mutation altering degron motif	0.7139
p.T195A	SIDM01711	Non-Cancerous	GDSC	VPSTS	DEG_SPOP_SBC_1	192:196	Mutation altering degron motif	0.7139
p.T195A	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	VPSTS	DEG_SPOP_SBC_1	192:196	Mutation altering degron motif	0.7139
p.T195A	SIDM01074	Glioblastoma	GDSC	VPSTS	DEG_SPOP_SBC_1	192:196	Mutation altering degron motif	0.7139
p.C200S	SIDM01519	Head and Neck Carcinoma	GDSC	VPSTS	DEG_SPOP_SBC_1	192:196	Mutation rewiring degron network	0.2222
p.C200S	ACH-000992	Head and Neck Cancer	CCLE	VPSTS	DEG_SPOP_SBC_1	192:196	Mutation rewiring degron network	0.2222
p.S191N	Daudi	haematopoietic and lymphoid tissue	COSMIC	VPSTS	DEG_SPOP_SBC_1	192:196	Mutation rewiring degron network	0.3056

Kaplan plot for UHRF2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

UHRF2

UniProt ID: Q96PU4

Entrez ID: 115426

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for UHRF2 in