DegronMD

Uniprot ID: Q96PU4

Source protein: E3 ubiquitin-protein ligase UHRF2

Source gene: UHRF2

Class: DEG_SPOP_SBC_1

Location: 192:196

E3 ligase: SPOP

DEGRON score: 0.993

ASA_SCORE: 79.86

COIL: 0.9372

CONS_SCORE: 0.2531

DSS_SCORE: 0.5161

HELIX: 0.0336

FCONS_SCORE: 0.9137

RIG_SCORE: 0.6505

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E184D	TCGA-AJ-A3EK	UCEC	TCGA	VPSTS	DEG_SPOP_SBC_1	0.1111
p.E184D	DO41584	UCEC	ICGC	VPSTS	DEG_SPOP_SBC_1	0.1111
p.S182F	TCGA-DK-AA6L	BLCA	TCGA	VPSTS	DEG_SPOP_SBC_1	0.0556
p.S182F	DO219002	BLCA	ICGC	VPSTS	DEG_SPOP_SBC_1	0.0556
p.T195M	TCGA-DS-A0VK	CESC	TCGA	VPSTS	DEG_SPOP_SBC_1	0.7423
p.T195M	DO6256	CESC	ICGC	VPSTS	DEG_SPOP_SBC_1	0.7423
p.D199Y	TCGA-EE-A3AD	SKCM	TCGA	VPSTS	DEG_SPOP_SBC_1	0.25
p.D199Y	DO37707	SKCM	ICGC	VPSTS	DEG_SPOP_SBC_1	0.25
p.T195A	SIDM00421	T-Cell Non-Hodgkin's Lymphoma	GDSC	VPSTS	DEG_SPOP_SBC_1	0.7139
p.T195A	SIDM01483	Melanoma	GDSC	VPSTS	DEG_SPOP_SBC_1	0.7139
p.T195A	SIDM00188	Kidney Carcinoma	GDSC	VPSTS	DEG_SPOP_SBC_1	0.7139
p.T195A	SIDM01711	Non-Cancerous	GDSC	VPSTS	DEG_SPOP_SBC_1	0.7139
p.T195A	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	VPSTS	DEG_SPOP_SBC_1	0.7139
p.T195A	SIDM01074	Glioblastoma	GDSC	VPSTS	DEG_SPOP_SBC_1	0.7139
p.C200S	SIDM01519	Head and Neck Carcinoma	GDSC	VPSTS	DEG_SPOP_SBC_1	0.2222
p.C200S	ACH-000992	Head and Neck Cancer	CCLE	VPSTS	DEG_SPOP_SBC_1	0.2222
p.S191N	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	VPSTS	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94966	Ubiquitin carboxyl-terminal hydrolase 19	DEG_SPOP_SBC_1	938:942	VPSTS	SPOP	0.9914	More...
O95665	Neurotensin receptor type 2	DEG_SPOP_SBC_1	240:244	VPSTS	SPOP	0.8867	More...
P24386	Rab proteins geranylgeranyltransferase component A 1	DEG_SPOP_SBC_1	188:192	VPSTS	SPOP	0.9827	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	4260:4264	VPSTS	SPOP	0.9795	More...
Q5THJ4	Intermembrane lipid transfer protein VPS13D	DEG_SPOP_SBC_1	2123:2127	VPSTS	SPOP	0.9469	More...
Q6VY07	Phosphofurin acidic cluster sorting protein 1	DEG_SPOP_SBC_1	777:781	VPSTS	SPOP	0.9965	More...
Q86WV6	Stimulator of interferon genes protein	DEG_SPOP_SBC_1	351:355	VPSTS	SPOP	0.9975	More...
Q92574	Hamartin	DEG_SPOP_SBC_1	640:644	VPSTS	SPOP	0.9829	More...
Q92772	Cyclin-dependent kinase-like 2	DEG_SPOP_SBC_1	389:393	VPSTS	SPOP	0.9663	More...
Q96PU4	E3 ubiquitin-protein ligase UHRF2	DEG_SPOP_SBC_1	192:196	VPSTS	SPOP	0.993	More...
Q9HCI5	Melanoma-associated antigen E1	DEG_SPOP_SBC_1	159:163	VPSTS	SPOP	0.9657	More...
Q8TBF4	Zinc finger CCHC-type and RNA-binding motif-containing protein 1	DEG_SPOP_SBC_1	191:195	VPSTS	SPOP	0.989	More...
P0C6C1	Ankyrin repeat domain-containing protein 34C	DEG_SPOP_SBC_1	426:430	VPSTS	SPOP	0.9869	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons