DegronMD

Uniprot ID: O94966

Source protein: Ubiquitin carboxyl-terminal hydrolase 19

Source gene: USP19

Class: DEG_SCF_FBW7_2

Location: 108:115

E3 ligase: FBXW7

DEGRON score: 0.9991

ASA_SCORE: 76.9875

COIL: 0.7664

CONS_SCORE: 0.2895

DSS_SCORE: 0.5025

HELIX: 0.1666

FCONS_SCORE: 0.987

RIG_SCORE: 0.7766

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H106D	TCGA-AC-A23H	BRCA	TCGA	LLATPTPE	DEG_SCF_FBW7_2	0.2778
p.H106D	DO2401	BRCA	ICGC	LLATPTPE	DEG_SCF_FBW7_2	0.2778
p.P105S	TCGA-EE-A2MT	SKCM	TCGA	LLATPTPE	DEG_SCF_FBW7_2	0.25
p.P105S	DO38051	SKCM	ICGC	LLATPTPE	DEG_SCF_FBW7_2	0.25
p.G100E	TCGA-EO-A22U	UCEC	TCGA	LLATPTPE	DEG_SCF_FBW7_2	0.1111
p.G100E	DO43755	UCEC	ICGC	LLATPTPE	DEG_SCF_FBW7_2	0.1111
p.H106N	TCGA-ER-A1A1	SKCM	TCGA	LLATPTPE	DEG_SCF_FBW7_2	0.2778
p.H106N	DO37413	SKCM	ICGC	LLATPTPE	DEG_SCF_FBW7_2	0.2778
p.S111F	DO51886	BLCA	ICGC	LLATPTPE	DEG_SCF_FBW7_2	0.7982
p.R118C	DO233207	GACA	ICGC	LLATPTPE	DEG_SCF_FBW7_2	0.25
p.P112H	DO228976	LICA	ICGC	LLATPTPE	DEG_SCF_FBW7_2	0.7694
p.P105T	DO229028	LICA	ICGC	LLATPTPE	DEG_SCF_FBW7_2	0.25
p.Y105S	DO231762	LINC	ICGC	LLATPTPE	DEG_SCF_FBW7_2	0.25
p.H124Y	SNU-175	large_intestine	COSMIC	LLATPTPE	DEG_SCF_FBW7_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94966	Ubiquitin carboxyl-terminal hydrolase 19	DEG_SCF_FBW7_2	108:115	LLATPTPE	FBXW7	0.9991	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons